PMID: 26320479Sep 1, 2015Paper

A Randomized Controlled Trial Comparing Clinical Outcomes and Toxicity of Lobaplatin- Versus Cisplatin-Based Concurrent Chemotherapy Plus Radiotherapy and High-Dose-Rate Brachytherapy for FIGO Stage II and III Cervical Cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Ji-Quan WangZi Liu

Abstract

We designed this randomized controlled trial (RCT) to assess whether lobaplatin-based concurrent chemotherapy might be superior to cisplatin-based concurrent chemotherapy for FIGO stage II and III cervical cancer in terms of efficacy and safety. This prospective, open-label RCT aims to enroll 180 patients with FIGO stage II and III cervical cancer, randomly allocated to one of the three treatment groups (cisplatin 15mg/m2, cisplatin 20mg/m2 and lobaplatin 35mg/m2), with 60 patients in each group. All patients will receive external beam irradiation (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT). Patients in cisplatin 15mg/m2 and 20mg/m2 groups will be administered four cycles of 15mg/m2 or 20mg/m2 cisplatin intravenously once weekly from the second week to the fifth week during EBRT, while patients inthe lobaplatin 35mg/m2 group will be administered two cycles of 35mg/m2 lobaplatin intravenously in the second and fifth week respectively during pelvic EBRT. All participants will be followed up for at least 12 months. Complete remission rate and progression-free survival (PFS) will be the primary endpoints. Overall survival (OS), incidence of adverse events (AEs), and quality of life will be the secondary endpoin...Continue Reading

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Jul 24, 2001·Medical and Pediatric Oncology·Y Tsuchida, P Therasse
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xin-En HuangJi-Feng Feng
Nov 19, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoqin LiDonghong Wang
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Nan WangJia-Rui Li

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Citations

Dec 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Furui ZhangGuoqiang Zhao
Mar 30, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jingchao He, Haijun Zhang

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