Abstract
Zileuton, a leukotriene pathway inhibitor, was compared with slowly absorbed theophylline in a randomized, double-blind study of patients with chronic asthma. The primary efficacy measure was improvement in forced expiratory volume in 1 second (FEV1). Eligibility criteria included FEV1 of 40% to 80% of predicted, documented reversibility of airway disease, and age 18 to 60 years. Initially, the theophylline dosage was titrated to achieve trough concentrations of 8 to 15 micrograms/mL. After washout and 1-week placebo lead-in, patients were randomly assigned to 13 weeks of the appropriate theophylline dose or zileuton, 400 or 600 mg 4 times daily. The FEV1 was measured before the morning dose at 2-week intervals and serially after the dose on days 36 and 92. Patients kept daily diaries of asthma symptoms, beta-agonist usage, and peak expiratory flow rate; on days 36 and 92, they completed quality-of-life questionnaires. Of 471 eligible patients at 38 centers, 377 were randomly assigned to the study; 313 completed the study. On first-dose administration, all groups showed 11% to 13% improvement in FEV1 within 30 minutes. Patients who received zileuton, 400 mg, had significantly greater improvement at several points than did theop...Continue Reading
Citations
Sep 9, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L García-Marcos, A Schuster
Jun 3, 2005·The Journal of Clinical Investigation·Andre BaficaJulio Aliberti
Aug 7, 1999·Clinical Reviews in Allergy & Immunology·S L Spector
Jun 1, 2000·Indian Journal of Pediatrics·G Gupta
Feb 29, 2000·The Journal of the American Osteopathic Association·S M Gawchik, C L Saccar
Mar 27, 2001·Family Practice·M EcclesUNKNOWN North of England Asthma Guideline Development Group
May 22, 2001·Veterinary Dermatology·R Marsella
May 5, 2001·Expert Opinion on Pharmacotherapy·L García-Marcos, A Schuster
Feb 28, 2001·Expert Opinion on Investigational Drugs·T C Theoharides, G R Sant
Mar 31, 2007·International Journal of Clinical Practice·W BergerC B Cairns
Feb 24, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M J Massanari
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S D Crowther, P J Rees
Jun 24, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P DevillierC Advenier
Dec 16, 1998·Respiratory Medicine·S J Lane
Apr 24, 2004·The Cochrane Database of Systematic Reviews·F DucharmeR Kakuma
Dec 13, 2017·Journal of Orthopaedic Surgery·Gen-Bin WuYun-Feng Yang
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Parameswaran NairBrian H Rowe
Aug 9, 2006·Medicinal Research Reviews·Valérie CapraG Enrico Rovati
Jun 16, 1999·Nature Genetics·J M DrazenJ Drajesk
Feb 27, 2001·Current Opinion in Pulmonary Medicine·J F Donohue, J A Ohar
Oct 19, 2004·The Nurse Practitioner·Kevin R MurphyNancy L Sarver
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Feb 26, 2008·European Journal of Pharmacology·Ben S ZweifelJaime L Masferrer