A randomized controlled trial evaluating sildenafil citrate in relieving ureteral stent-related symptoms

World Journal of Urology
Mohamed TharwatAhmed R El-Nahas

Abstract

To evaluate the role of sildenafil in relieving ureteral stent symptoms. A randomized controlled trial was conducted between March 2014 and November 2016. It included adult men who underwent unilateral ureteric stent after ureteroscopy. Patients who were taking PDE5-Is, alpha-blockers or anticholinergics, had contraindication to sildenafil or developed postoperative complications were not included. Eligible patients were randomized using sealed closed envelops to one of two groups (S and C). Patients in group S received sildenafil citrate 50 mg tablet once daily. Patients in group C were the control. All patients answered the ureteral stent symptom questionnaire (USSQ) after 2 weeks of stenting. Primary outcome was the difference in total USSQ score between both groups. Secondary outcomes were tolerability of the treatment and the difference in each domain of USSQ score. After randomization, four patients (7.3%) in group C withdraw their consent because of severe symptoms and two patients (3.6%) in group S discontinued treatment because of headache and dizziness. Final analysis was performed for 46 and 48 patients in groups C and S, respectively. Total USSQ score and all domains (except work performance) were significantly lowe...Continue Reading

References

Jan 24, 2006·Journal of Endourology·Ahmed R El-NahasHamdy A El-Kappany
Apr 21, 2009·The Journal of Urology·James E LingemanUNKNOWN Comfort Study Team
Aug 21, 2010·The Journal of Urology·Athanasios DellisFrancis X Keeley
Apr 2, 2011·BJU International·Alastair D LambOliver J Wiseman
May 29, 2015·Arab Journal of Urology·Ahmed R El-NahasKhaled Z Sheir
Apr 30, 2016·Journal of Endourology·Christopher KoprowskiSammy E Elsamra

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Citations

Dec 4, 2019·Nature Biomedical Engineering·Christopher X LeeMichael J Cima
Apr 21, 2020·World Journal of Urology·Xiaopeng LiYongliang Ni
Sep 25, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Gaurav Mohan Sali, Hrishikesh B Joshi
Aug 18, 2020·Research and Reports in Urology·Meghana RamachandraBhaskar K Somani

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