A randomized controlled trial evaluating nutrition counseling with or without oral supplementation in malnourished HIV-infected patients

Journal of the American Dietetic Association
L RabeneckS S Akrabawi

Abstract

To evaluate the effects of nutrition counseling with or without oral supplementation in malnourished patients infected with the human immunodeficiency virus (HIV). Randomized controlled trial. HIV-infected men (n=118) who were less than 90% of usual weight for height or who had lost more than 10% of body weight. Nutrition counseling alone (control group) vs nutrition counseling plus enteral supplementation (supplement group) for 6 weeks. All patients were instructed to consume a diet that exceeded estimated total energy expenditure by 960 kcal/day. Weight, skinfold thickness, fat-free mass, grip strength, quality of life, and cognitive function (Buschke test). Differences in baseline variables and outcomes were evaluated using analysis of variance or the Wilcoxon rank sum test. Ninety-nine men completed at least 4 weeks of treatment, 49 in the supplement group and 50 in the control group. Half the patients in each treatment group achieved at least 80% of their energy target. No differences in weight, skinfold thickness measurements, or quality of life were observed. Compared with the control group, the supplement group had larger increases in fat-free mass and grip strength, although the differences did not reach statistical si...Continue Reading

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Citations

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