A Randomized Controlled Trial of Continuous Positive Airway Pressure on Glucose Tolerance in Obese Patients with Obstructive Sleep Apnea

Sleep
Neus SalordMercedes Mayos

Abstract

Obstructive sleep apnea (OSA) is associated with an increased prevalence of metabolic syndrome (MetS), even in patients with morbid obesity. Our goal was to address whether continuous positive airway pressure (CPAP) treatment improved glucose metabolism in this population. A prospective randomized controlled trial was performed in severe OSA patients with morbid obesity without diabetes in two university referral hospitals. Patients received conservative (CT) versus CPAP treatment for 12 weeks. MetS components, homeostasis model assessment of insulin resistance (HOMA-IR) and oral glucose tolerance were assessed at baseline and after treatment. A total of 80 patients completed the study (42 CPAP and 38 CT patients). After 12 w of CPAP treatment, weight loss was similar in both groups and physical activity, prevalence of MetS, and HOMA-IR did not change in either group. In the CPAP group impaired glucose tolerance (IGT) reversed in nine patients and IGT developed in none, whereas IGT reversed in five patients and IGT developed in five patients in the CT group (P = 0.039 in the Fisher test). Changes in 2-h plasma glucose after glucose load were greater in the CPAP group than in the CT group (CPAP: -0.5 ± 1.5 versus CT: 0.33 ± 1.9,...Continue Reading

References

Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Sep 27, 2003·American Journal of Respiratory and Critical Care Medicine·Igor A HarschJoachim H Ficker
Jul 30, 2004·American Journal of Respiratory and Critical Care Medicine·Juan F MasaJosé M Montserrat
Sep 30, 2005·American Journal of Respiratory and Critical Care Medicine·Kevin J ReichmuthTerry Young
Jan 26, 2007·The European Respiratory Journal·S R CoughlinP M A Calverley
Mar 1, 2007·Diabetes Care·David M NathanUNKNOWN American Diabetes Association
Feb 6, 2008·Proceedings of the American Thoracic Society·Mark H SandersRachel J Givelber
Sep 9, 2008·The American Journal of Cardiology·John S HoShannon J FitzGerald
Jul 2, 2009·The European Respiratory Journal·P LévyJ Eckel
Nov 17, 2010·Nature Reviews. Cardiology·Malcolm Kohler, John R Stradling
May 31, 2011·The European Respiratory Journal·M GasaC Monasterio
Sep 17, 2011·The European Respiratory Journal·M R BonsignoreJ Eckel
Oct 14, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jamie Chung Mei LamMary Sau Man Ip
Apr 24, 2013·Annals of the American Thoracic Society·Imran H IftikharUlysses J Magalang
Sep 3, 2013·European Respiratory Review : an Official Journal of the European Respiratory Society·Maria R BonsignoreRon Grunstein

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Citations

Aug 22, 2018·Frontiers in Endocrinology·Sarah N Framnes, Deanna M Arble
Aug 19, 2018·Current Diabetes Reports·Rachel P Ogilvie, Sanjay R Patel
May 2, 2019·The Journal of Clinical Endocrinology and Metabolism·Peter Y Liu
Feb 1, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Carla López-PadrósCarmen Monasterio
Aug 4, 2018·The Clinical Respiratory Journal·Gonzalo LabarcaLauren Drake
Oct 17, 2019·Frontiers in Aging Neuroscience·Caitlin M Carroll, Shannon L Macauley
Mar 14, 2017·Expert Review of Respiratory Medicine·Michelle T CaoC Guilleminault
Jul 1, 2016·The Journal of Physiology·Craig L PhillipsRonald R Grunstein
Nov 11, 2019·NPJ Primary Care Respiratory Medicine·Mercè MayosM Antònia Llauger
Jul 28, 2020·International Journal of Obesity Supplements·Giovanna MuscogiuriUNKNOWN Obesity Programs of nutrition, Education, Research and Assessment (OPERA) group
Jun 15, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Abd A Tahrani
Jul 29, 2016·Current Opinion in Cardiology·Michael A GrandnerDaniel Combs
Feb 6, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Camilla M HoyosSanjay R Patel
Nov 3, 2020·World Journal of Gastroenterology : WJG·Alejandro Campos-MurguíaRicardo U Macías-Rodríguez

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