A randomized controlled trial of fludrocortisone for the treatment of hyperkalemia in hemodialysis patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Mohammed O KaisarDavid W Johnson

Abstract

Previous small uncontrolled studies suggested that fludrocortisone may significantly decrease serum potassium concentrations in hemodialysis patients, possibly through enhancement of colonic potassium secretion. The aim of this study is to evaluate the effect of oral fludrocortisone on serum potassium concentrations in hyperkalemic hemodialysis patients in an open-label randomized controlled trial. Thirty-seven hemodialysis patients with predialysis hyperkalemia were randomly allocated to administration of either oral fludrocortisone (0.1 mg/d; n = 18) or no treatment (control; n = 19) for 3 months. The primary outcome measure was midweek predialysis serum potassium concentration, which was measured monthly during the trial. Prospective power calculations indicated that the study had an 80% probability of detecting a decrease in serum potassium levels of 0.7 mEq/L (0.7 mmol/L). Baseline patient characteristics were similar, except for slightly longer total weekly dialysis hours in the fludrocortisone group (13.0 +/- 1.3 versus 12.1 +/- 1.0; P = 0.02). At the end of the study period, no significant changes in serum potassium concentrations were observed between the fludrocortisone and control groups (4.8 +/- 0.5 versus 5.2 +/- 0...Continue Reading

References

Feb 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S HouM Beach
Jan 1, 1987·American Journal of Nephrology·A H Tzamaloukas, P S Avasthi
Jun 1, 1980·Kidney International·G MorrisonJ Morganroth
Jan 1, 1993·American Journal of Nephrology·P C SinghalJ K Maesaka
Jun 26, 2001·Kidney International·J A KarnikG M Chertow
Jan 22, 2003·Seminars in Dialysis·Louis J ImbrianoJohn K Maesaka

❮ Previous
Next ❯

Citations

Sep 22, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Meghan J ElliottBrenda R Hemmelgarn
Jun 19, 2015·The American Journal of the Medical Sciences·Sahil AgrawalMark Segal
Aug 6, 2015·Seminars in Dialysis·Samantha Dias Suthar, John P Middleton
Jul 15, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aidar R GosmanovCsaba P Kovesdy
Sep 28, 2007·Seminars in Dialysis·Nirupama Putcha, Michael Allon
Mar 28, 2008·Seminars in Dialysis·Jean-Sebastien Rachoin, Lawrence S Weisberg
Dec 3, 2010·Seminars in Dialysis·Ron Zanger
Oct 1, 2013·Seminars in Dialysis·Sarah SanghaviJaime Uribarri
May 16, 2014·Seminars in Dialysis·Laura Labriola, Michel Jadoul
Aug 16, 2013·Electrolyte & Blood Pressure : E & BP·Hoon Young Choi, Sung Kyu Ha
Aug 6, 2017·Journal of the American Society of Nephrology : JASN·John R Montford, Stuart Linas
Jan 11, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Peter N Van BurenRobert D Toto
Mar 7, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Shilpa VijayakumarGeorge L Bakris
Apr 10, 2018·Kidney Research and Clinical Practice·Yuri SeoSoon Bae Kim
Sep 21, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simonetta GenovesiUNKNOWN EUDIAL Working Group of ERA-EDTA
Apr 5, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·S J H DobbinG A McKay
Mar 13, 2021·Transplantation Reviews·Bassem AlmalkiAkansha Agrawal
Jul 23, 2021·Reviews in Endocrine & Metabolic Disorders·John G RizkKamyar Kalantar-Zadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Dong-Min KimHyun Lee Kim
Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Govarthanan RajendiranAshwin Kumar Mani
© 2022 Meta ULC. All rights reserved