A randomized controlled trial of increased dose and frequency of albendazole with standard dose DEC for treatment of Wuchereria bancrofti microfilaremics in Odisha, India

PLoS Neglected Tropical Diseases
Shantanu Kumar KarCherubala P Ramachandran

Abstract

Although current programmes to eliminate lymphatic filariasis have made significant progress it may be necessary to use different approaches to achieve the global goal, especially where compliance has been poor and 'hot spots' of continued infection exist. In the absence of alternative drugs, the use of higher or more frequent dosing with the existing drugs needs to be explored. We examined the effect of higher and/or more frequent dosing with albendazole with a fixed 300 mg dose of diethylcarbamazine in a Wuchereria bancrofti endemic area in Odisha, India. Following screening, 104 consenting adults were randomly assigned to treatment with the standard regimen annually for 24 months (S1), or annually with increased dose (800 mg albendazole)(H1) or with increased frequency (6 monthly) with either standard (S2) or increased (H2) dose. Pre-treatment microfilaria counts (GM) ranged from 348 to 459 mf/ml. Subjects were followed using microfilaria counts, OG4C3 antigen levels and ultrasound scanning for adult worm nests. Microfilarial counts tended to decrease more rapidly with higher or more frequent dosing at all time points. At 12 months, Mf clearance was marginally greater with the high dose regimens, while by 24 months, there wa...Continue Reading

References

Jan 18, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Hanan HelmyReda M R Ramzy
Nov 4, 2008·Current Opinion in Infectious Diseases·Achim Hoerauf
Nov 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benoit DembeleAmy D Klion
Nov 10, 2011·Clinical Ophthalmology·Olufemi Emmanuel Babalola
Jan 9, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Wládia LimaCynthia Braga

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Citations

Jan 9, 2019·The Cochrane Database of Systematic Reviews·Cara L MacfarlanePaul Garner
Jul 22, 2019·Tropical Medicine and Infectious Disease·Malina A Bakowski, Case W McNamara

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