A randomized controlled trial of light versus deep propofol sedation for elective outpatient colonoscopy: recall, procedural conditions, and recovery

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Megan AllenPaul Maruff

Abstract

This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, patient clinical recovery, and post-procedure cognitive impairment. Two hundred patients undergoing elective outpatient colonoscopy were randomized to light (bispectral index [BIS] 70-80) or deep (BIS < 60) sedation with propofol and fentanyl. Recall was assessed by the modified Brice questionnaire, and cognition at baseline and discharge was assessed using a Cogstate test battery. The median (interquartile range [IQR]) BIS values were different in the two groups (69 [65-74] light sedation vs 53 [46-59] deep sedation; P < 0.0001). The incidence of recall was 12% in the light sedation group and 1% in the deep sedation group. The risk difference for recall was 0.11 (90% confidence interval, 0.05 to 0.17) in the intention-to-treat analysis, thus refuting equivalence in recall between light and deep sedation (0.05 significance level; 10% equivalence margin). Overall sedation-related complications were more frequent with deep sedation than with light sedation (66% vs 47%, respectively; P = 0.008). Recovery was more rapid with light sedation than with deep sedation as dete...Continue Reading

References

Jun 1, 1970·British Journal of Anaesthesia·D D BriceJ E Utting
Jul 1, 1969·Health Physics·N Ohen, T J Kneip
Nov 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F Chung
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Jul 27, 2001·Acta Anaesthesiologica Scandinavica·G BarrJ G Jakobsson
Nov 26, 2005·Journal of General Internal Medicine·Thomas D DenbergDennis J Ahnen
Mar 1, 2006·Gastroentérologie Clinique Et Biologique·Thomas CrepeauGilles Bommelaer
Dec 11, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mohammed A QadeerGregory Zuccaro
Jun 17, 2009·European Journal of Anaesthesiology·Audrey Singyi EerKate Leslie
Sep 22, 2010·Journal of General Internal Medicine·Esteban Walker, Amy S Nowacki
Dec 21, 2010·Gastrointestinal Endoscopy·Chang Kyun LeeSun-Joo Kim
May 11, 2013·Anaesthesia and Intensive Care·N ChatmanN Abraham

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Citations

Aug 27, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Matthew T V ChanRaymond S Y Tang
May 20, 2016·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kate LesliePhillip Clarke
Jun 6, 2018·Current Opinion in Anaesthesiology·Joshua W Sappenfield, Jeffrey D White
Nov 28, 2018·Current Medical Research and Opinion·Seho LimHyun Kang
Sep 16, 2017·Current Opinion in Anaesthesiology·Kate Leslie, Benjamin Kave
Sep 25, 2017·Current Opinion in Anaesthesiology·Stephan Knigge, Klaus Hahnenkamp
Apr 9, 2020·Journal of Bronchology & Interventional Pulmonology·Erez Ben-MenachemAdrian P Havryk
Jun 29, 2016·World Journal of Gastroenterology : WJG·Bin-Bin XuGui-Ping Xu
Jul 28, 2016·Anaesthesia and Intensive Care·K LeslieA Y-S Lee

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