PMID: 9164692May 1, 1997Paper

A randomized, controlled trial of linopirdine in the treatment of Alzheimer's disease

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
K RockwoodS Gauthier

Abstract

We tested the efficacy and safety of linopirdine, a novel phenylindolinone, in the treatment of Alzheimer's disease. A multicentre, randomized, double-blind, parallel group, placebo-controlled trial of linopirdine (30 mg three times per day or placebo). Patients (n = 382, 55% male, 98% Caucasian, age range 51-95 years) with mild or moderate Alzheimer's disease, of whom 375 received at least one treatment dose were analysed. There were no important differences between the groups at baseline. No difference was seen in Clinical Global Impression scores between patients receiving placebo and those receiving linopirdine (n = 189). Small differences in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) scores were seen throughout the study favouring linopirdine; at 6 months the ADAS-Cog scores were 20.2 (linopirdine) and 22.1 (placebo) p = 0.01. This trial did not detect clinically meaningful differences in patients receiving linopirdine for 6 months, despite evidence of a small degree of improved cognitive function. Further studies may benefit from more sensitive tests of treatment effects in Alzheimer's disease.

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Citations

May 2, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kenneth Rockwood
Mar 21, 2009·British Journal of Pharmacology·David A Brown, Gayle M Passmore
Jul 29, 2015·PloS One·Jennifer Mayordomo-CavaLydia Jiménez-Díaz
Sep 20, 2000·Alzheimer Disease and Associated Disorders·K Rockwood, P Stolee
May 10, 2017·The Journal of Pharmacology and Experimental Therapeutics·Derek L GreeneNaoto Hoshi
Mar 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Jennifer van der HorstThomas A Jepps
Dec 16, 1998·Current Opinion in Neurology·S Gauthier
Jan 20, 2006·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Gina BravoMarie-France Dubois
Jan 1, 1998·International Journal of Psychiatry in Clinical Practice·M Rainer, H A Mucke
Apr 28, 2018·Clinical and Experimental Pharmacology & Physiology·Sean P NassoiyMatthias Majetschak
Feb 15, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M T FerrettiR Schmidt
Nov 11, 1998·Journal of the American Geriatrics Society·K RockwoodP McCracken
Nov 17, 2020·Frontiers in Physiology·Nina DirkxSarah Weckhuysen
May 14, 2004·Journal of Medicinal Chemistry·Yong-Jin WuSteven I Dworetzky
Aug 23, 2002·Pharmacology & Therapeutics·Alan Wickenden
May 29, 2021·RSC Medicinal Chemistry·Matteo BorginiPeter Wipf

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