A Randomized Controlled Trial of Liposomal Bupivacaine Parasternal Intercostal Block for Sternotomy

The Annals of Thoracic Surgery
Candice Y LeePeter A Knight

Abstract

Optimal pain control continues to be a concern in cardiac surgery. Current strategies for postoperative pain management often yield suboptimal results. The superiority of Exparel (Pacira Pharmaceuticals, Inc, Parsippany, NJ) in providing postoperative pain control and opioid sparing is equivocal. This prospective, randomized, double-blind study examines the efficacy of Exparel as a novel single-dose application parasternal nerve block in postoperative pain control and opioid sparing. This single-surgeon study included 79 patients undergoing median sternotomy for coronary revascularization. Study participants were randomized to either the drug or a control arm. Each participant received Exparel or normal saline placebo administered as a parasternal nerve block. Postoperative pain was rated according to the nonverbal pain scale or numeric rating scale. Total amount of narcotic pain medication used and patients' pain scores within the first 72 hours postoperatively were compared. Secondary outcomes compared the intensive care unit length of stay, hospital length of stay, time to extubation, time to return of bowel function, and time to return to work or daily activities. The primary endpoint of pain levels between the two groups d...Continue Reading

Citations

Oct 1, 2019·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Mario Castillo-SangGeoffrey A Answini
Jun 25, 2020·Journal of Cardiac Surgery·Sri Rama Ananta Nagabhushanam PadalaAjay Kumar Jha
Nov 30, 2019·Frontiers in Immunology·Larissa PessoaMarcelo Freire
Apr 11, 2020·Annals of Cardiac Anaesthesia·Prachi Kar, Gopinath Ramachandran
Jan 18, 2020·Nanoscale Research Letters·Yumiao HeChao Ma
Jun 25, 2020·Pharmaceutics·Lisa Rahnfeld, Paola Luciani
Oct 25, 2020·Current Pain and Headache Reports·Alan David KayeElyse M Cornett
Sep 23, 2020·Minerva anestesiologica·Ece Yamak Altinpulluk, Alparslan Turan
Mar 1, 2020·The Journal of Thoracic and Cardiovascular Surgery·Abbas E Abbas
Jan 13, 2021·Minerva anestesiologica·Stanley Jablonski, Philipp Lirk
Oct 19, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Jason OchrochJesse Raiten
May 4, 2021·Seminars in Cardiothoracic and Vascular Anesthesia·Nathan ClendenenNathaen Weitzel
Jun 2, 2021·Veterinary Anaesthesia and Analgesia·Francesco ZublenaFederico Corletto
Jun 11, 2021·Journal of Cardiac Surgery·Soojie Yu, Oscar D Aljure

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.