Abstract
To determine whether an oral sucrose solution improves pain response for infants undergoing bladder catheterization in an emergency department (ED) population. A randomized, double-blinded study comparing the analgesic effects of a sucrose solution to placebo for infants < or = 90 days of age and requiring bladder catheterization. Infants with prior bladder catheterization, previous painful procedures that day, or neurological or genital abnormalities were excluded. Infants were assigned baseline pain scores and then given 2 mL of sucrose or water 2 minutes before catheterization. Trained pediatric ED nurses rated the infants for pain, presence of cry, and time to return to baseline. Eighty-three patients were enrolled; 40 were randomized to sucrose, and 40, to placebo. Baseline pain scores were similar within each age group. Overall, sucrose did not produce a significant analgesic effect. In subgroup analysis, infants 1-30 days of age receiving sucrose showed a smaller change in pain scores (2.9 vs. 5.3, p = 0.035), were less likely to cry with catheterization (29% vs. 72%, p = 0.008), and returned to baseline more rapidly after catheter removal (10 seconds vs. 37 seconds, p = 0.04) compared with infants who received placebo. ...Continue Reading
References
Jan 1, 1988·Pharmacology, Biochemistry, and Behavior·E M Blass, E Fitzgerald
Jun 1, 1995·Pain·C C JohnstonL Horton
Jun 10, 1995·BMJ : British Medical Journal·N HaouariM Levene
Feb 12, 1998·Biology of the Neonate·K J Anand
Apr 8, 1998·Archives of Pediatrics & Adolescent Medicine·M HerschelR Mittendorf
Jul 11, 1998·Archives of Disease in Childhood·P J LewindonN Lewindon
Sep 22, 1998·Archives of Pediatrics & Adolescent Medicine·R S Van Howe, C J Cold
Mar 30, 1999·Biology of the Neonate·C Overgaard, A Knudsen
Apr 8, 1999·Archives of Disease in Childhood·I Abu-ArafehS Hislop
Oct 8, 1999·Pediatrics in Review·K B Roberts
Nov 27, 1999·BMJ : British Medical Journal·R CarbajalM Olivier-Martin
Feb 15, 2001·Archives of Pediatrics & Adolescent Medicine·K J Anand, UNKNOWN International Evidence-Based Group for Neonatal Pain
Aug 8, 2002·Pediatrics·Ricardo CarbajalAlain Paupe
Sep 3, 2002·Pediatrics·C Celeste JohnstonKristina Boyer
Nov 12, 2003·Archives of Pediatrics & Adolescent Medicine·Anna TaddioJoel Katz
Nov 12, 2003·Archives of Pediatrics & Adolescent Medicine·Evelyn Cohen ReisRichard Holubkov
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·A B AcharyaD Field
Nov 3, 2004·Pediatrics·William T ZempskyUNKNOWN American Academy of Pediatrics Committee on Pediatric Emergency Medicine and Section on Anesthesiology and Pain Medicine
Jan 8, 2005·Nurse Researcher·Patriek MistiaenCordula Wagner
Apr 5, 2005·Pediatrics·Maria Gradin, Jens Schollin
Jun 7, 2006·Circulation·Lee A FleisherUNKNOWN Society for Vascular Medicine and Biology
Citations
Mar 28, 2008·The American Journal of Nursing·Brigitte M BaumannKathleen Newbury
Jul 7, 2011·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Linda A HatfieldRosemary C Polomano
Oct 15, 2013·Annals of Emergency Medicine·Erica A Michiels, John D Hoyle
Mar 25, 2008·Annals of Emergency Medicine·Sharon E MaceUNKNOWN EMSC Panel (Writing Committee) on Critical Issues in the Sedation of Pediatric Patients in the Emergency
Mar 6, 2007·Lancet·Frank Shann
Dec 22, 2010·Japan Journal of Nursing Science : JJNS·Takahiro Kakeda
Mar 1, 2011·Nursing & Health Sciences·Takahiro Kakeda, Toshizo Ishikawa
Feb 15, 2011·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·John D HoyleRachel M Stanley
Nov 8, 2014·Journal for Specialists in Pediatric Nursing : JSPN·Derya Uzelli, Ülkü Yapucu Güneş
Dec 10, 2013·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Sally WilsonDiane Pearson
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Manal KassabCathrine Fowler
May 6, 2015·The Cochrane Database of Systematic Reviews·Denise HarrisonBonnie Stevens
Jul 16, 2016·The Cochrane Database of Systematic Reviews·Bonnie StevensAllyson Shorkey
Jul 19, 2019·Journal of Paediatrics and Child Health·Kevin LondonAnthony Liu
Dec 18, 2019·Paediatrics & Child Health·Evelyne D TrottierSamina Ali
Mar 17, 2010·Journal of Perioperative Practice·Teresa Hardcastle
Feb 3, 2012·Critical Care Nurse·Tracy Ann Pasek, Jessica Marie Huber
Aug 1, 2020·The Lancet Child & Adolescent Health·Cian WadeMike English
Apr 3, 2021·The Journal of Emergency Medicine·Serge GouinNathalie Gaucher
Apr 15, 2019·International Journal of Nursing Studies·Charles LamyPascale Beloni
May 27, 2021·CJEM·Marie Pier DesjardinsSerge Gouin
Oct 10, 2012·Pediatrics·Denise HarrisonBonnie Stevens
Oct 13, 2010·Pediatrics·Denise HarrisonBonnie Stevens