PMID: 9641434Jun 26, 1998Paper

A randomized controlled trial of the effect of naproxen on delayed onset muscle soreness and muscle strength

Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine
J M LecomteD L Montgomery

Abstract

To determine the effect of naproxen in attenuating the symptoms (muscle soreness level) and signs (plasma creatine kinase [CK] activity and muscular strength decrement) of delayed onset muscle soreness (DOMS) induced by repeated bouts of eccentric exercise. The design was a randomized, double-blind, placebo-controlled, crossover trial with two testing phases of 8 days' duration that were separated by a "washout" period of 7 days. University-based sports science center. Twenty healthy male volunteers who responded to a notice in the university's athletic complex. Eccentric single-leg exercises were performed on days 1, 3, and 4 to induce DOMS in the quadriceps muscles. Naproxen or placebo tablets (500 mg) were taken orally twice per day beginning on day 2 and continuing until the end of the testing phase. Perception of muscle soreness and knee extensor torque were evaluated daily throughout each phase. Plasma CK levels were evaluated on days 1, 3, 6, and 8 of each phase. After the eccentric exercise, plasma CK levels were similarly elevated in both naproxen and placebo conditions (F=1.42; p=0.25). After DOMS developed, naproxen reduced the perception of soreness on day 3, when muscle soreness was highest (F=2.20; p=0.04). After ...Continue Reading

Citations

Dec 25, 2010·European Journal of Applied Physiology·Emma WichardtKarin Henriksson-Larsén
Apr 28, 1999·Trends in Microbiology·D V Kalvakolanu
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