A Randomized Controlled Trial of the Safety and Immunogenicity of Tetanus, Diphtheria, and Acellular Pertussis Vaccine Immunization During Pregnancy and Subsequent Infant Immune Response

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Scott A HalperinDeborah Money

Abstract

Immunization of pregnant women with tetanus-diphtheria-acellular pertussis vaccine (Tdap) provides protection against pertussis to the newborn infant. In a randomized, controlled, observer-blind, multicenter clinical trial, we measured the safety and immunogenicity of Tdap during pregnancy and the effect on the infant's immune response to primary vaccination at 2, 4, and 6 months and booster vaccination at 12 months of age. A total of 273 women received either Tdap or tetanus-diphtheria (Td) vaccine in the third trimester and provided information for the safety analysis and samples for the immunogenicity analyses; 261 infants provided serum for the immunogenicity analyses. Rates of adverse events were similar in both groups. Infants of Tdap recipients had cord blood levels that were 21% higher than maternal levels for pertussis toxoid (PT), 13% higher for filamentous hemagglutinin (FHA), 4% higher for pertactin (PRN), and 7% higher for fimbriae (FIM). These infants had significantly higher PT antibody levels at birth and at 2 months and significantly higher FHA, PRN, and FIM antibodies at birth and 2 and 4 months, but significantly lower PT and FHA antibody levels at 6 and 7 months and significantly lower PRN and FIM antibody l...Continue Reading

Associated Clinical Trials

Nov 4, 2007·Scott Halperin

References

Aug 18, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S A HalperinP Duclos
Jul 18, 2003·The Pediatric Infectious Disease Journal·Charles R VitekTrudy V Murphy
Nov 15, 2003·The Journal of Pediatrics·Lynda K MikelovaUNKNOWN Members of the Immunization Monitoring Program, Active (IMPACT)
Feb 3, 2004·American Journal of Infection Control·Judith Morrison, UNKNOWN Health Canada, Nosocomial and Occupational Infections Section
Jun 1, 1951·The Journal of Pediatrics·P COHENE DUBOW
Nov 17, 2004·The Pediatric Infectious Disease Journal·Kristine M BisgardSusan M Lett
Sep 1, 1938·The Journal of Clinical Investigation·J A LichtyW L Bradford
Sep 29, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B A HalperinS A Halperin
Jul 24, 2012·The Journal of Pediatrics·Kathleen WinterGilberto Chavez
Oct 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gavin DabreraMary Ramsay
May 6, 2015·Pediatrics·Tejpratap S P TiwariThomas A Clark
Jun 18, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen WinterJames D Cherry
Sep 17, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shamez N LadhaniElizabeth Miller
Sep 17, 2015·The Pediatric Infectious Disease Journal·Tina TanCarl Heinz Wirsing von König
Apr 20, 2016·BMJ Open·Helen Petousis-HarrisNikki Turner
Nov 3, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen WinterKathleen Harriman
Nov 14, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria Yui Kwan ChowPeter McIntyre
Nov 14, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kirsten MaertensElke Leuridan
Nov 14, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gayatri AmirthalingamNick Andrews
Feb 9, 2017·Obstetrics and Gynecology·Mark McMillanHelen S Marshall

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Citations

Mar 17, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Viviana RomaninCarla Vizzotti
Jul 19, 2019·Expert Review of Vaccines·Angela GentileElsa Sarti
May 16, 2019·Minerva ginecologica·Alessio MesiniElio Castagnola
Sep 20, 2019·Infectious Diseases and Therapy·Charlotte SwitzerDenis Macina
Nov 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne-Sophie DebrieCamille Locht
Oct 17, 2019·Journal of Travel Medicine·Roni NasserAmi Neuberger
Apr 19, 2020·Current Opinion in Infectious Diseases·Thomas F RiceBeate Kampmann
Aug 17, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nasamon WanlapakornElke Leuridan
Jun 23, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bahaa Abu-Raya
Oct 28, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eleonora BrilloErsilia Buonomo
May 10, 2020·Science·Tobias R KollmannSing Sing Way
Mar 19, 2019·Journal of Immunology Research·Carolina Argondizo-CorreiaCyro Alves de Brito
Sep 19, 2019·Infectious Diseases and Therapy·Caroline D'HeillyDenis Macina
Jan 9, 2020·European Journal of Pediatrics·Kirsten MaertensElke Leuridan
Feb 15, 2020·BMC Infectious Diseases·Sabine Vygen-BonnetThomas Harder
Oct 21, 2020·CMAJ Open·Bahaa Abu-RayaUNKNOWN for members of the Canadian Immunization Monitoring Program, ACTive (IMPACT)
Jan 3, 2021·NeoReviews·Bahaa Abu-Raya, Kirsten Maertens
May 28, 2019·The Lancet Infectious Diseases·Maurizio Bonati, Antonio Clavenna
Mar 23, 2021·Vaccine·Natasha S CrowcroftGayatri Amirthalingam
Apr 6, 2021·Vaccine: X·Lourdes R A Vaz-de-LimaUNKNOWN Maternal Pertussis Vaccine Working Group
May 28, 2021·The Pediatric Infectious Disease Journal·Petra Zimmermann, Christine E Jones
May 11, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kirsten MaertensElke Leuridan
Nov 15, 2021·American Journal of Obstetrics and Gynecology·Melanie EttiPaul T Heath
Dec 2, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marjolein R P OrijeElke Leuridan

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