A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal females.

The Journal of Clinical Endocrinology and Metabolism
Kate A WardM Z Mughal

Abstract

There has been a resurgence of vitamin D deficiency rickets throughout the developed world, with infants and adolescents being primarily affected. Adolescence is a crucial period for muscle and bone mineral accumulation. The aim was to determine the effect of vitamin D supplementation on the adolescent musculoskeletal system. We conducted a community-based, double-blind, randomized controlled trial in a secondary school. Postmenarchal 12- to 14-yr-old females participated in the trial. Ninety-nine were screened, 73 were included in randomized controlled trial, and 69 completed the trial. There were no adverse events. Four doses of 150,000 IU vitamin D(2) (ergocalciferol) were given over 1 yr. Dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and jumping mechanography were used. At follow-up, 25-hydroxyvitamin D [25(OH)D] status was 56.0 ± 8.9 nmol/liter in the intervention group and 15.8 ± 6.6 nmol/liter in controls. There were no effects of supplementation on bone; however, for muscle function, efficiency of movement improved in the vitamin D-treated group. There was an interaction between baseline 25(OH)D concentration and response to vitamin D supplementation for muscle jump velocity. Despite imp...Continue Reading

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