A randomized cross-over study of auto-continuous positive airway pressure versus fixed-continuous positive airway pressure in patients with obstructive sleep apnoea

Respirology : Official Journal of the Asian Pacific Society of Respirology
Kin W ToDavid S Hui

Abstract

To compare the efficacy of auto-CPAP (AutoSet Spirit, ResMed) versus fixed-CPAP (S6 Elite, ResMed) in improving daytime sleepiness, health status, objective compliance and the ultimate treatment preference in patients with severe OSA. The study recruited 43 subjects aged 18-65 years with newly diagnosed severe OSA (AHI >30/h). Patients were initially treated with either auto-CPAP or fixed-CPAP for 2 months and then crossed over after a washout period of 1 week for another 2 months. The study was completed by 41 patients. Results are presented as mean (SE). Use of auto-CPAP in the first and the second month was significantly higher than that of fixed-CPAP [129.7 (9.9) and 130.5 (10.7) h vs 115.2 (9.5) and 113.2 (9.4) h, P = 0.04 and 0.01], whereas mean hourly use per night was 4.3 and 4.4 h versus 3.8 and 3.7 h, respectively. The Epworth sleepiness scores improved after 1 month in both treatments (13.4 to 8.5 and 8.2, P < 0.01 for both). The Sleep apnoea quality of life index improved in the first month in both compared with baseline [4.6 (0.2) to 5.0 (0.2) for auto-CPAP and 4.9 (0.2) for fixed-CPAP, P = 0.01 and 0.04, respectively], with no difference between the two treatments. Nine and 30 patients preferred auto-CPAP and fixe...Continue Reading

References

Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·H TeschlerN Konietzko
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·P LloberesR Rodriguez-Roisin
Oct 6, 1997·The European Respiratory Journal·H TeschlerM Berthon-Jones
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Ramon FarréDaniel Navajas
Jul 30, 2004·American Journal of Respiratory and Critical Care Medicine·Juan F MasaJosé M Montserrat
Feb 1, 2005·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·O RestaG Insalaco
Mar 25, 2005·The New England Journal of Medicine·Apoor S GamiVirend K Somers
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·David S C HuiChristopher K W Lai

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Citations

Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Clifford A MassieNeil J Douglas
Oct 4, 2003·American Journal of Respiratory and Critical Care Medicine·Oliver SennKonrad E Bloch
Feb 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Eric D PowellAtul Malhotra
Sep 2, 2010·Sleep Medicine Clinics·Omer Ahmed, Sairam Parthasarathy
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Ian Smith, Toby J Lasserson
Mar 27, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Maliheh Ghadiri, Ronald R Grunstein

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