PMID: 11907389Mar 22, 2002Paper

A randomized, double-blind comparison of ondansetron versus placebo for prevention of nausea and vomiting after infratentorial craniotomy

Journal of Neurosurgical Anesthesiology
J M FablingC O Borel

Abstract

Ondansetron was compared with placebo for nausea and vomiting prophylaxis after fentanyl/isoflurane/relaxant anesthesia and infratentorial craniotomy. Eight milligrams intravenous ondansetron or vehicle was administered at skin closure. Nausea, emesis, and antiemetic use were recorded at 0, 0.5, 1, 4, 8, 12, 24, and 48 hours. There were no significant intergroup differences for nausea incidence at any interval, but cumulatively the placebo group was 3.2 times more likely to develop nausea during the first 12 hours (P = .04). Nausea incidence was bimodal in both groups, peaking during the first 1 to 4 hours. A nadir occurred at 8 to 12 hours, but nausea increased during the next 36 hours. By 48 hours, approximately 40% of patients in both groups were still nauseated. Reduced vomiting frequency was seen with ondansetron at 4, 8, 12, and 24 hours (P < .05). Despite rescue antiemetics, emesis occurred in an irregular pattern with episodes still observed in 35% of placebo patients at 48 hours. For ondansetron, emesis was infrequent for the first 12 hours but then a persistent increase was observed (48 hours, 22%). The incidence of rescue antiemetic use was 65% for both groups. There was no effect of gender. Nausea and vomiting are f...Continue Reading

References

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Citations

May 4, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·G Audibert, V Vial
Jul 11, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Kazuyoshi KoriToshiaki Minami
Oct 30, 2010·Journal of Neurosurgery·Björn LatzKristin Engelhard
Feb 22, 2008·Best Practice & Research. Clinical Anaesthesiology·L H J EberhartS Himmelseher
Jun 19, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ayumu KuwamuraToshiaki Minami
Jun 23, 2006·Anesthesia and Analgesia·Brigid C Flynn, Edward C Nemergut
Jan 2, 2007·Journal of Neurosurgical Anesthesiology·Susan M Neufeld, Christine V Newburn-Cook
Mar 24, 2010·Journal of Neurosurgical Anesthesiology·Xiao-Qiang WangXiang Gao
Mar 15, 2006·Current Opinion in Anaesthesiology·Kate Leslie, Daryl L Williams
Jun 6, 2019·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·M I KlyukinA Yu Lubnin
Oct 5, 2006·Current Opinion in Anaesthesiology·Nicolas J Bruder
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Jul 13, 2019·Current Opinion in Pharmacology·Yasmin SchmidSimon M Mueller
May 4, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·A M DebailleulR Krivosic-Horber

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