A randomized double-blind controlled study on the efficacy of laser zona pellucida thinning on live birth rates in cases of advanced female age

Human Reproduction
N FrydmanR Fanchin

Abstract

It is conceivable that defective embryo hatching plays a part in the mechanisms involved in the decrease of embryo implantation rates with advancing age. In an effort to test this hypothesis, we tested the effectiveness of assisted hatching (AH) in women > or =37 years of age. We prospectively studied 103 IVF-embryo transfer patients undergoing 103 embryo transfers. All of them were > or =37 years of age and had <3 previous IVF-embryo transfer attempts. Laser-AH of transferred embryos was either performed (AH group, n = 49) or not (control group, n = 54) according to randomized and double-blind methodology. Primary outcome was live birth rate. Population characteristics were comparable in AH and control groups as well as the mean number of embryos transferred (2.7 +/- 0.6 versus 2.7 +/- 0.6) and the prevalence of top quality embryos transferred (65 versus 59%, respectively). We failed to find any statistically significant difference between AH and control groups with regard to implantation (16.1 versus 16.7%, respectively) and live birth rates (22.4 versus 29.6%, respectively). The present study indicates that AH does not improve IVF-embryo transfer outcome in women aged > or =37 years.

References

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Dec 14, 2004·Reproductive Biomedicine Online·Nelly FrydmanRené Frydman

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Citations

May 16, 2009·Archives of Gynecology and Obstetrics·Hakan YaraliBulent Tiras
Nov 3, 2010·Journal of Assisted Reproduction and Genetics·Mohamad Eid HammadehKhaled Refaat Ali
Apr 9, 2011·Human Reproduction Update·Wellington P MartinsCarolina O Nastri
Mar 21, 2013·Reproductive Biology and Endocrinology : RB&E·Chanchai ChailertTeraporn Vutyavanich
Oct 23, 2008·Systems Biology in Reproductive Medicine·Janos KoncSandor Cseh
Apr 7, 2009·Gynécologie, obstétrique & fertilité·J Blessmann-RosetB Macé
Mar 10, 2016·Zygote : the Biology of Gametes and Early Embryos·Katalin KanyoJanos Konc
Jan 20, 2018·Journal of Assisted Reproduction and Genetics·Alessandra AlteriPatrizia Rubino
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Sarah-Kate CarneyLinsey Nelson
Mar 18, 2021·The Cochrane Database of Systematic Reviews·Lauren LaceyM Ahsan Akhtar
Feb 2, 2010·Reproductive Biomedicine Online·Mojtaba Rezazadeh ValojerdiBahar Movaghar

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