A randomized, double-blind, controlled trial of the effect of prebiotic oligosaccharides on enteral tolerance in preterm infants (ISRCTN77444690)

Pediatric Research
Neena ModiElena Kulinskaya

Abstract

Breast milk prebiotic oligosaccharides are believed to promote enteral tolerance. Many mothers delivering preterm are unable to provide sufficient milk. We conducted a multicenter, randomized, controlled trial comparing preterm formula containing 0.8 g/100 mL short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides in a 9:1 ratio and an otherwise identical formula, using formula only to augment insufficient maternal milk volume. Infants were randomized within 24 h of birth. The primary outcome (PO) was time to establish a total milk intake of 150 mL/kg/d PO and the principal secondary outcome (PSO) was proportion of time between birth and 28 d/discharge that a total milk intake of ≥ 150 mL/kg/d was tolerated. Other secondary outcomes included growth, fecal characteristics, gastrointestinal signs, necrotizing enterocolitis, and bloodstream infection. Outcomes were compared adjusted for prespecified covariates. We recruited 160 infants appropriately grown for GA <33 wk. There were no significant differences in PO or PSOs. After covariate adjustment, we showed significant benefit from trial formula in PSO with increasing infant immaturity (2.9% improved tolerance for a baby born at 28-wk gestation and 9.9% at 26-wk ...Continue Reading

References

Aug 15, 2000·Annual Review of Nutrition·C KunzS Strobel
Apr 30, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·G BoehmA Marini
Nov 29, 2002·Pediatrics·Walter A MihatschFrank Pohlandt
Oct 16, 2004·The New England Journal of Medicine·James Madara
Mar 25, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·Catherine A BoydPeter Brocklehurst
Dec 26, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N B DassG J Sanger
May 22, 2008·The Journal of Pediatrics·Flavia IndrioRuggiero Francavilla
May 24, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·N ModiA Holmes
Jun 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·Flavia IndrioGünther Boehm

❮ Previous
Next ❯

Citations

Aug 22, 2013·Early Human Development·Silvia Fanaro
Nov 8, 2012·European Journal of Pediatrics·Nicky NieleRuurd M van Elburg
Mar 6, 2013·The Journal of Pediatrics·Teresa Murguía-PenicheJosef Neu
Apr 2, 2013·The Cochrane Database of Systematic Reviews·David A Osborn, John K H Sinn
Oct 14, 2014·World Journal of Gastroenterology : WJG·Petra A M J ScholtensAnnamaria Staiano
Aug 20, 2019·The Cochrane Database of Systematic Reviews·Amir Mohammad ArmanianErfan Sadeghi
Aug 17, 2021·Frontiers in Nutrition·Safiyyah AbbasAlice R Rumbold

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.