A randomized, double-blind, dose-finding Phase II study to evaluate immunogenicity and safety of the third generation smallpox vaccine candidate IMVAMUNE.

Vaccine
Alfred von KrempelhuberPaul J Chaplin

Abstract

IMVAMUNE is a Modified Vaccinia Ankara (MVA)-based virus that is being developed as a safer 3rd generation smallpox vaccine. In order to determine the optimal dose for further development, a double-blind, randomized Phase II trial was performed testing three different doses of IMVAMUNE in 164 healthy volunteers. All three IMVAMUNE doses displayed a favourable safety profile, with local reactions as the most frequent observation. The 1 x 10(8)TCID(50) IMVAMUNE dose induced a total antibody response in 94% of the subjects following the first vaccination and the highest peak seroconversion rates by ELISA (100%) and PRNT (71%). This IMVAMUNE dose was considered to be optimal for the further clinical development of this highly attenuated poxvirus as a safer smallpox vaccine.

References

Nov 27, 1969·The New England Journal of Medicine·J M LaneJ D Millar
Apr 20, 1970·JAMA : the Journal of the American Medical Association·J M LaneJ D Millar
Mar 30, 2002·The New England Journal of Medicine·Sharon E FreyUNKNOWN National Institute of Allergy and Infectious Diseases Smallpox Vaccine Study Group
Jun 26, 2003·JAMA : the Journal of the American Medical Association·John D Grabenstein, William Winkenwerder
Jul 19, 2003·The Journal of Infectious Diseases·Jody ManischewitzHana Golding
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Linda S WyattBernard Moss
May 4, 2004·Journal of the American College of Cardiology·Dimitri C CassimatisMarina N Vernalis
Sep 24, 2004·American Journal of Epidemiology·Mark K ArnessDavid N Tornberg
Mar 24, 2005·The Journal of General Virology·Mansun LawGeoffrey L Smith
May 28, 2005·Journal of Virology·Koert J StittelaarAlbert D M E Osterhaus
Jun 14, 2005·Nature Medicine·Yvette Edghill-SmithGenoveffa Franchini
Feb 9, 2007·Journal of Virology·April Keim ParkerR Mark L Buller
Nov 21, 2007·The Journal of General Virology·Christine Meisinger-HenschelJürgen Hausmann
Apr 10, 2008·The Journal of Clinical Investigation·Christofer SamuelssonHubertus Hochrein
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patricia L EarlBernard Moss
Nov 21, 2008·Journal of Virology·Mohammed Rafii-El-Idrissi BenhniaShane Crotty
Dec 20, 2008·Expert Review of Vaccines·Jeffrey S Kennedy, Richard N Greenberg
Dec 31, 2008·The American Journal of Medicine·Junko SanoSharon E Frey
Apr 3, 2009·The Journal of General Virology·Inger K DamonKevin Karem

❮ Previous
Next ❯

Citations

Dec 14, 2011·Virology Journal·Patricia S RicciGeorg W Holzer
Mar 18, 2011·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·D A Henderson
Feb 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer L ReedMike Bray
Aug 23, 2011·Expert Review of Vaccines·Stephen R Walsh, Raphael Dolin
Apr 9, 2015·Viruses·Lucas Sánchez-SampedroMariano Esteban
Mar 26, 2013·Vaccine·Matthew G Cottingham, Miles W Carroll
Jan 27, 2015·Journal of Biopharmaceutical Statistics·Walthère DewéMarc Fourneau
Jan 5, 2011·Immunological Reviews·Bernard Moss
Jul 11, 2012·Human Vaccines & Immunotherapeutics·Paulo H VerardiCaitlin J Hagen
Jun 9, 2016·Expert Review of Vaccines·Ian J Amanna, Mark K Slifka
May 22, 2018·Biotechnology & Genetic Engineering Reviews·Les P NagataDavid H Evans
May 6, 2016·Clinical and Vaccine Immunology : CVI·Dorothy I JonesHerman F Staats
Jul 6, 2014·Clinical and Vaccine Immunology : CVI·Hiroyuki YokoteSo Hashizume
Feb 17, 2018·Scientific Reports·Jean-Louis PalgenAnne-Sophie Beignon
Jul 6, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Saurabh SaigalDinesh Kumar Singh
Aug 26, 2017·Expert Review of Vaccines·Lynette Siv Chea, Rama Rao Amara
Feb 9, 2018·Frontiers in Immunology·Stephanie L SanosHenning Lauterbach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.