A randomized, double-blind, multicenter comparison of gatifloxacin versus ciprofloxacin in the treatment of complicated urinary tract infection and pyelonephritis

Clinical Therapeutics
Clair E CoxJoanna Y Yang

Abstract

Gatifloxacin is a fluoroquinolone antibiotic with a broad spectrum of in vitro and in vivo activity against the gram-negative and gram-positive pathogens frequently implicated in urinary tract infections (UTIs). This study compared the clinical and bacteriologic efficacy and tolerability of gatifloxacin versus ciprofloxacin in adult patients with complicated UTIs or pyelonephritis. In this double-blind, multicenter, randomized, comparative study, patients were treated with either gatifloxacin 400 mg once daily or ciprofloxacin 500 mg twice daily for 7 to 10 days. Bacteriologic eradication (by quantitative urine culture) and clinical efficacy rates were assessed at a test-of-cure visit (5 to 9 days and 4 to 11 days posttreatment, respectively) and at an extended follow-up visit (29-42 days and 25-50 days posttreatment, respectively). A total of 372 adults were randomized to treatment, 189 to gatifloxacin and 183 to ciprofloxacin. The most commonly isolated pretreatment pathogens (n = 292) were Escherichia coli (53%) and Klebsiella pneumoniae (13%). Pathogen eradication rates for complicated UTIs were 92% and 83% with gatifloxacin and ciprofloxacin, respectively (95% CI, -4.1% to 24.5%); for pyelonephritis, the respective rates w...Continue Reading

References

Sep 9, 1982·The New England Journal of Medicine·R PlattB Rosner
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C M Kunin
Aug 1, 1996·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·W R Jarvis
Oct 6, 1997·Infectious Disease Clinics of North America·A R Ronald, G K Harding
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·X ZhaoK Drlica
Jun 30, 1998·Home Healthcare Nurse·E Haus
Jan 12, 1999·British Journal of Urology·S J Eykyn
Aug 10, 2000·International Journal of Antimicrobial Agents·M D Melekos, K G Naber
Apr 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J HobanR N Jones

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Citations

Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard Frothingham
Nov 14, 2003·The Pediatric Infectious Disease Journal·Adriano ArguedasPhillip F Pierce
Mar 23, 2007·Clinical Pharmacokinetics·Florian M E WagenlehnerKurt G Naber
Apr 26, 2006·Expert Opinion on Investigational Drugs·Adam D Hickerson, Culley C Carson
Jan 15, 2008·International Journal of Antimicrobial Agents·Barbara G PiccoliMauro Frascisco
Jul 21, 2006·International Journal of Antimicrobial Agents·Giorgina B PiccoliG Piccoli
Aug 17, 2004·Infectious Disease Clinics of North America·Judith A O'Donnell, Steven P Gelone
May 20, 2004·The Annals of Pharmacotherapy·Karla M KillgoreB Joseph Guglielmo
Jan 24, 2017·Environmental Science and Pollution Research International·Ayub KhanXiangke Wang
Sep 8, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jonathan W S CattrallAndrew Kirby
Jun 24, 2010·Expert Opinion on Pharmacotherapy·Devon C Snow, Daniel A Shoskes

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