PMID: 11906651Mar 22, 2002Paper

A randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of a Chinese herbal product (P07P) for the treatment of canine atopic dermatitis

Veterinary Dermatology
T M NagleM T Stevens

Abstract

A randomized, double-blind, placebo-controlled trial of P07P, a product derived from a traditional Chinese herbal remedy, was undertaken in 50 dogs with atopic dermatitis. Owners recorded a daily itch score for 4-14 days before treatment and during treatment. Packets of powder containing P07P or placebo were added to the food once daily for 8 weeks. Dogs were assessed for erythema, surface damage, overall coat condition and seborrhoea by the same investigator, as well as for pruritus and general demeanour, at 0 (visit 2), 28 (visit 3) and 56 (visit 4) days of treatment or at withdrawal. Investigator and owner assessments of response were recorded after 28 and 56 days of treatment or at withdrawal. The predefined primary outcome measure was the owners' assessment of response at the end of treatment. Nine of the 24 dogs (37.5%) in the P07P group but only 3 of the 23 dogs (13%) in the placebo group were considered to have improved, but this difference was not statistically significant (P = 0.09). There was a significantly higher withdrawal rate due to worsening of condition in the placebo group (P = 0.04). Mean daily itch score in the second 28-day period of the study was significantly higher than baseline in the placebo group (P ...Continue Reading

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Citations

Nov 28, 2012·The Veterinary Clinics of North America. Small Animal Practice·Jeanne B Budgin, Molly J Flaherty
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Tae Ho ChungJin Yeul Ma
Jun 7, 2003·Veterinary Dermatology·T OlivryUNKNOWN International Task Force on Canine Atopic Dermatitis
Sep 12, 2007·Veterinary Dermatology·P B HillJ Rybnicek
Mar 16, 2007·Veterinary Dermatology·Thierry OlivryUNKNOWN International Task Force On Canine Atopic Dermatitis
Mar 2, 2010·Veterinary Dermatology·Vanessa SchmidtTim Nuttall
Mar 2, 2010·Veterinary Dermatology·Thierry OlivryHywel C Williams
Mar 14, 2002·Clinical Techniques in Small Animal Practice·Susan G Wynn, Stephanie Chalmers
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Sep 13, 2013·The Cochrane Database of Systematic Reviews·Weiya ZhangHywel C Williams
Apr 28, 2019·Journal of Acupuncture and Meridian Studies·Justin ShmalbergMushtaq A Memon

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.