A randomized, double-blind, placebo-controlled trial of pseudoephedrine in coryza

Clinical and Experimental Pharmacology & Physiology
Jenny LatteSepehr Shakib

Abstract

1. The aim of the present study was to assess the efficacy of pseudoephedrine in coryza. 2. In a double-blind, randomized, placebo-controlled design, 48 adults with acute coryza received a single oral dose of 60 mg pseudoephedrine (Sudafed; Pfizer Consumer HealthCare Group, Caringbah, NSW, Australia) or matching placebo. Before and after dosing, nasal airway resistance (NAR), nasal volume, the minimum intranasal cross-sectional area (MCA) and the symptom of nasal congestion were measured. 3. Pseudoephedrine produced a significant decrease in NAR (P = 0.005; 95% confidence interval (CI) 0.073, 0.383). Nasal volume increased, but this did not reach significance (P = 0.07; 95% CI -0.842, 0.034). There was no change in MCA and symptoms. 4. In conclusion, pseudoephedrine has a moderate effect in decreasing objective measures of nasal congestion in coryza.

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Citations

Sep 28, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard M RosenfeldDavid L Witsell
Jun 25, 2013·The Journal of Allergy and Clinical Immunology·William T BarchukXuejun Liu
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Nov 2, 2016·The Cochrane Database of Systematic Reviews·Laura DeckxMieke L van Driel

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