A randomized, double-blind, placebo-controlled, crossover, dose-ranging multicenter study to determine the effect of sublingual nitroglycerin spray on exercise capacity in patients with chronic stable angina.

Clinical Medicine Insights. Cardiology
Udho Thadani, Thomas Wittig

Abstract

Sublingual nitroglycerin increases exercise duration in patients with stable angina. Brief results from this study were published previously in German. Here, we more fully describe the study methodology, patient characteristics, and detailed results. This double-blind, crossover study enrolled 51 patients with stable angina. Patients were randomized to 1 of 5 treatment sequences and were administered placebo or nitroglycerin spray (0.2 mg, 0.4 mg, 0.8 mg, or 1.6 mg). Patients carried out 1 control exercise tolerance test (ETT) and 1 investigational ETT at each visit. Dose-dependent increases in time to onset of angina, time to onset of moderate angina, and the occurrence of a minimum 1.0-mm ST-segment depression were seen following administration of nitroglycerin spray. These results support the use of sublingual nitroglycerin spray in patients with stable angina who are being managed with medical therapy and in patients who have persistent angina post-revascularization.

References

Jan 1, 1986·The American Journal of Cardiology·J O ParkerB Farrell
Jan 1, 1980·Chest·R J Stuart, M H Ellestad
Aug 1, 1994·Cardiovascular Drugs and Therapy·U Thadani, R J Lipicky
Jun 26, 1997·The American Journal of Cardiology·U Thadani
Apr 12, 2001·The New England Journal of Medicine·P W SerruysUNKNOWN Arterial Revascularization Therapies Study Group
Jan 8, 2003·Circulation·Jonathan Myers
Feb 7, 2003·Journal of the American College of Cardiology·Raymond J GibbonsUNKNOWN American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable An
Sep 17, 2003·Circulation·Thomas B Graboys, Bernard Lown
Sep 21, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·Udho Thadani
Jun 20, 2006·American Heart Journal·William E BodenUNKNOWN COURAGE trial coprincipal investigators and study coordinators
Oct 10, 2006·European Heart Journal·Emmanuel I Skalidis, Panos E Vardas
Mar 28, 2007·The New England Journal of Medicine·William E BodenUNKNOWN COURAGE Trial Research Group
Aug 16, 2008·The New England Journal of Medicine·William S WeintraubG B J Mancini
Jun 9, 2009·The New England Journal of Medicine·UNKNOWN BARI 2D Study GroupBurton E Sobel
Jul 27, 2011·The American Journal of Medicine·Prakash C Deedwania, Enrique V Carbajal

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Citations

Mar 26, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Udho Thadani
May 23, 2014·The American Journal of Medicine·William E BodenNanette K Wenger
Jun 18, 2016·Cardiovascular Drugs and Therapy·Jason M Tarkin, Juan Carlos Kaski
Sep 24, 2016·Expert Opinion on Drug Safety·Talla A RousanUdho Thadani
Jan 26, 2017·Drugs·Talla A RousanUdho Thadani
May 24, 2014·Nature Reviews. Drug Discovery·Bronwyn A KingwellNorman E Miller

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Methods Mentioned

BETA
percutaneous transluminal coronary angioplasty

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