A randomized, double-blind study of valsartan versus metoprolol on arterial distensibility and endothelial function in essential hypertension

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Markus KoschMartin Hausberg

Abstract

Antihypertensive drugs may have differential, pressure-independent effects on hypertension-associated alterations of arterial function. We compared the effects of a 12-week therapy with the AT(1)-receptor antagonist valsartan (Val) versus the beta-blocker metoprolol (Met) on arterial stiffness and endothelial function in mildly hypertensive patients at rest and during generalized sympathetic stimulation. Sixty-eight patients (37 male, 31 female, 46 +/- 6 years) were randomized to Val (80-160 mg/d) or Met (50-100 mg/d). Effects of therapy on endothelial function, brachial and carotid artery distensibility coefficients, pulse wave velocity, carotid intima-media thickness and elastic modulus were assessed at rest and during the cold pressor test. Fifty-two patients were available for per protocol analysis. Blood pressure was comparably reduced in both treatment groups. Effects on endothelial function and large artery elastic wall properties did not differ significantly between the two antihypertensive treatment regimens. Trends did not differ significantly between groups for any parameter including carotid intima-media thickness and elastic modulus. Short-term treatment with Val and Met had similar effects on large artery function...Continue Reading

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Citations

Jun 2, 2010·Current Hypertension Reports·Asia Rehman, Ernesto L Schiffrin
Oct 6, 2012·American Journal of Nephrology·Valerie BartelsDetlef Lang
Jan 14, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·George NtaiosApostolos Hatzitolios
May 1, 2012·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Charalambos KoumarasAsterios Karagiannis
Oct 20, 2009·Current Medical Research and Opinion·Francesco LocatelliTevfik Ecder
Apr 11, 2012·International Journal of Vascular Medicine·Michiaki MiyamotoNobuyuki Taniguchi
Apr 10, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Feng PengWenquan Niu
Sep 22, 2011·European Journal of Preventive Cardiology·Mojca LunderMiso Sabovic
Mar 22, 2015·Vascular Medicine·Ami B BhattMark A Creager
May 7, 2009·Current Opinion in Cardiology·Michala E Pedersen, John R Cockcroft

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