A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients

Breast Cancer Research and Treatment
Angel ArnaoutMark Clemons

Abstract

Chloroquine has demonstrated anti-tumor activities through autophagy inhibition and cell cycle disruption. This study aimed to assess the effect of single-agent chloroquine on breast tumor cellular proliferation in a randomized, phase II, double-blind, placebo-controlled, pre-surgical window of opportunity trial. Patients with newly diagnosed breast cancer were randomized 2:1 to chloroquine 500 mg daily or placebo for 2- to 6-weeks prior to their breast surgery. The primary outcome was the relative change in measures of proliferation (Ki67) in primary breast cancer cells pre- and post-treatment. Adverse events and toxicity profiles were also evaluated. From September 2015 to December 2016, 70 patients were randomized [46 (66%) chloroquine and 24 (34%) placebo]. Ten patients who were randomized to chloroquine withdrew from study due to adverse events. Mean duration of drug intake was 15 days (range 14-29 days). There were no significant differences between the chloroquine or placebo arms with respect to either the percentage change (- 0.4 vs. - 1.2, p = 0.088) or absolute change (- 2.0% vs. - 5.2%, p = 0.066) in Ki67 index pre- and post-drug treatment. Although adverse effects were minimal and all classified as grade 1, the effe...Continue Reading

References

Feb 25, 2005·Neurosurgical Focus·Eduardo BriceñoJulio Sotelo
Jul 24, 2008·Histochemistry and Cell Biology·Lawrence D True
Oct 23, 2008·Journal of the American College of Cardiology·Anthony N DeMaria
Dec 18, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Pei-du JiangYu-quan Wei
Dec 24, 2008·Annals of the Rheumatic Diseases·G Ruiz-IrastorzaM A Khamashta
Feb 16, 2010·The Lancet Oncology·Rinat YerushalmiKaren A Gelmon
Jan 18, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Glimelius, M Lahn
Feb 5, 2011·Ophthalmology·Michael F MarmorUNKNOWN American Academy of Ophthalmology
May 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin Kalinsky, Dawn L Hershman
Aug 31, 2012·Breast Cancer Research and Treatment·Saroj NiraulaPamela J Goodwin
Nov 10, 2013·Journal of the National Cancer Institute·Mei-Yin C PolleyUNKNOWN International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group
Jun 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine L CookRobert Clarke
Feb 13, 2015·Clinical Reviews in Allergy & Immunology·Nathalie Costedoat-ChalumeauMichael F Marmor
Feb 17, 2015·International Journal of Surgical Oncology·Angel ArnaoutMark Clemons
Mar 4, 2015·Current Medical Research and Opinion·Yuan ZhangHong-tao Xiao
Dec 22, 2015·European Journal of Pharmacology·Steve Pascolo
Feb 2, 2016·Cancer Treatment Reviews·Sandra SchmitzJean-Pascal Machiels
Mar 20, 2016·British Journal of Anaesthesia·S HeschlM Rigaud
Nov 1, 2016·Apoptosis : an International Journal on Programmed Cell Death·Xuan PuStewart G Martin
Nov 28, 2016·Cancer Chemotherapy and Pharmacology·Ting-Ting ShiHong-Tao Xiao
Jun 18, 2017·International Journal of Molecular Sciences·Cynthia I Chude, Ravi K Amaravadi
Jul 29, 2017·Nature Reviews. Cancer·Jean M Mulcahy LevyAndrew Thorburn
Sep 14, 2018·Frontiers in Oncology·Patrick WeyerhäuserElla L Kim
Jan 22, 2019·Theranostics·Kai ZhengYifei Wang

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Citations

May 16, 2020·Frontiers in Pharmacology·Ferda KaleağasıoğluMartin R Berger
Jul 25, 2020·Journal of Hematology & Oncology·Chaeuk ChungEun-Kyeong Jo
Jun 25, 2020·International Journal of Molecular Sciences·Jan HrabětaTomáš Eckschlager
May 5, 2020·Open Forum Infectious Diseases·Katelyn A PastickDavid R Boulware
Dec 29, 2020·Journal of the National Cancer Institute·Torsten O NielsenDaniel F Hayes
Oct 28, 2020·International Journal of Molecular Sciences·Stefania CoccoMichelino De Laurentiis
Dec 31, 2020·Viruses·Stephen D Carro, Sara Cherry
Jun 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Na-Ra HanHi-Joon Park
Jul 17, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Priyanila MageshPadmanaban S Suresh
Aug 5, 2021·Molecular and Cellular Biochemistry·Huimin SunChangchun Zeng
Oct 16, 2021·IUBMB Life·Reui-Liang Yan, Ruey-Hwa Chen
Sep 11, 2021·The Journal of Pharmacology and Experimental Therapeutics·Kristen M Van Eaton, Daniel L Gustafson

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