A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance

American Journal of Ophthalmology
Stephen C PflugfelderRoger Vogel

Abstract

To evaluate loteprednol etabonate ophthalmic 0.5% suspension, versus placebo for treatment of the inflammatory component of keratoconjunctivitis sicca in patients with delayed tear clearance. Randomized, double-masked, placebo-controlled clinical trial. Sixty-four patients with keratoconjunctivitis sicca and delayed tear clearance were randomly assigned to receive either loteprednol or vehicle 4 times a day for 4 weeks. Patients were evaluated at weeks 2 and 4 of treatment and 2 weeks after treatment was discontinued. Symptoms were scored using a visual analog scale (VAS) of 1 to 100. Corneal fluorescein staining was scored 0 to 4 in five areas. Conjunctival injection was graded 0 to 3 in the inferior bulbar, nasal bulbar, and inferior tarsal areas. Lid margin injection was graded 0 to 3. Safety was assessed by funduscopy, lens examination, biomicroscopy, visual acuity, and Goldmann tonometry, and by monitoring adverse events and changes in symptoms. In subsets of patients with at least moderate clinical inflammation, there was a significant difference between the loteprednol-treated group and vehicle-treated group after 2 weeks of therapy. The differences did not reach statistical significance at 4 weeks, although the lotepred...Continue Reading

References

Jun 17, 1998·Ophthalmology·C A McCartyH R Taylor
Nov 3, 1998·The British Journal of Ophthalmology·P Prabhasawat, S C Tseng
Jul 13, 2000·Ophthalmology·A MacriS Pflugfelder
Sep 12, 2000·Archives of Ophthalmology·S E MossB E Klein
Sep 29, 2000·Cornea·S C PflugfelderM E Stern
Nov 18, 2000·American Journal of Ophthalmology·A SolomonS C Pflugfelder
Feb 5, 2002·Experimental Eye Research·D Q LiS C Pflugfelder
Jun 12, 2003·Ophthalmology·Cintia Sade de PaivaStephen C Pflugfelder
Nov 1, 2006·The Ocular Surface·Stephen C Pflugfelder

❮ Previous
Next ❯

Citations

Jan 11, 2012·Archives of Ophthalmology·William StevensonReza Dana
May 25, 2012·Japanese Journal of Ophthalmology·Veysi OnerYalçın Işcan
Nov 7, 2012·Current Allergy and Asthma Reports·Simon E SkalickyPeter McCluskey
May 3, 2012·Nature Reviews. Rheumatology·Manuel Ramos-CasalsAthanasios G Tzioufas
Apr 27, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sanjay N Rao
Jun 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Claudio VitaliPierluigi Cataleta
Mar 19, 2013·Italian Journal of Pediatrics·Mario La RosaAlfredo Reibaldi
Jul 18, 2006·Journal of Zhejiang University. Science. B·Chong-qing YangYang-shun Gu
Aug 12, 2009·Clinical Ophthalmology·George D KymionisCharalambos Siganos
Feb 6, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Emrullah BeyazyıldızTuncay Delibaşi
Sep 10, 2014·Journal of Ophthalmology·Anushree Sharma, Holly B Hindman
Apr 27, 2012·International Journal of Inflammation·Timothy L Comstock, Heleen H Decory
Nov 25, 2014·International Ophthalmology·Ayse Yagci, Canan Gurdal
Jan 21, 2016·Ocular Immunology and Inflammation·Timothy L Comstock, Heleen H DeCory
Feb 26, 2014·Expert Review of Clinical Immunology·Stephen C Pflugfelder
Apr 30, 2014·Expert Opinion on Pharmacotherapy·Basilio ColligrisJesus Pintor
Oct 4, 2013·Expert Opinion on Investigational Drugs·Murat DogruKazuo Tsubota
Jul 1, 2014·Current Eye Research·Samanthila WaduthantriLouis Tong
Feb 20, 2016·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Laura E DownieAlgis J Vingrys
Oct 6, 2009·Optometry : Journal of the American Optometric Association·Erin McCabe, Srihari Narayanan
Nov 6, 2008·Rheumatic Diseases Clinics of North America·Gary N Foulks
Nov 11, 2008·American Journal of Ophthalmology·Helene LamStephen C Pflugfelder
Aug 24, 2007·Seminars in Arthritis and Rheumatism·Aikaterini Thanou-Stavraki, Judith A James
Mar 18, 2016·Advances in Therapy·John D SheppardMegan E Cavet
Aug 2, 2008·American Journal of Ophthalmology·Yuichi HoriYasuo Tano
Oct 16, 2015·BMC Ophthalmology·Aileen SyJennifer Rose-Nussbaumer
Jan 26, 2016·Expert Opinion on Drug Safety·Jolien F van NimwegenArjan Vissink
Feb 24, 2006·American Journal of Ophthalmology·Cintia S De PaivaStephen C Pflugfelder
Oct 25, 2011·American Journal of Ophthalmology·Stephen C Pflugfelder
Mar 20, 2012·Progress in Retinal and Eye Research·Stefano BarabinoReza Dana
Jul 1, 2015·Drugs & Aging·Nisreen S EzuddinAnat Galor
Oct 4, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Hui Lin, Samuel C Yiu
Oct 4, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Neda AfsharkhamsehAli R Djalilian
Apr 18, 2015·The Ocular Surface·Gary N FoulksDeborah S Jacobs
Nov 29, 2011·The American Journal of Pathology·Yoshikuni NakamuraShigeru Kinoshita

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here