A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence

Drug and Alcohol Dependence
Kathleen M CarrollS A Ball

Abstract

This study evaluated the extent to which the addition of disulfiram and contingency management for adherence and abstinence (CM), alone and in combination, might enhance the effects of cognitive behavioral therapy (CBT) for cocaine use disorders. Factorial randomized double blind (for medication condition) clinical trial where CBT served as the platform and was delivered in weekly individual sessions in a community-based outpatient clinic. 99 outpatients who met DSM-IV criteria for current cocaine dependence were assigned to receive either disulfiram or placebo, and either CM or no CM. Cocaine and other substance use was assessed via a daily calendar with thrice weekly urine sample testing for 12 weeks with a one-year follow-up (80% interviewed at one year). The primary hypothesis that CM and disulfiram would produce the best cocaine outcomes was not confirmed, nor was there a main effect for disulfiram. For the primary outcome (percent days of abstinence, self report), there was a significant interaction, with the best cocaine outcomes were seen for the combination of CM and placebo, with the two groups assigned to disulfiram associated with intermediate outcomes, and poorest cocaine outcome among those assigned to placebo and...Continue Reading

References

Dec 1, 1992·Alcoholism, Clinical and Experimental Research·J P Allen, R Z Litten
Dec 1, 1984·Controlled Clinical Trials·L M YoungJ P van Eeckhout
Dec 1, 1994·Journal of Studies on Alcohol. Supplement·R L StoutF K Del Boca
Apr 1, 1994·Drug and Alcohol Dependence·D A ZanisM Randall
Mar 1, 1994·Archives of General Psychiatry·K M CarrollF H Gawin
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·F K Del BocaP F Korner
Jan 8, 2000·Journal of Studies on Alcohol·T F BaborF Del Boca
May 1, 2001·The American Journal of Psychiatry·N M PetryT R Kosten
Jul 28, 2004·Drug and Alcohol Dependence·Kathleen M CarrollBruce J Rounsaville
Aug 2, 2005·The American Journal of Psychiatry·Kathleen M Carroll, Lisa S Onken
Feb 1, 2006·Addiction·Jennifer Plebani LussierStephen T Higgins
Sep 19, 2006·Drug and Alcohol Dependence·Jennifer R BakerElinore F McCance-Katz
Aug 1, 2007·Journal of Consulting and Clinical Psychology·Samuel A BallUNKNOWN National Institute on Drug Abuse Clinical Trials Network
Dec 19, 2007·Journal of Consulting and Clinical Psychology·Nancy M PetrySean Sierra
Jan 17, 2008·The American Journal of Psychiatry·Lissa DutraMichael W Otto

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Citations

Sep 21, 2016·Journal of Substance Abuse Treatment·Margaret C WardleJoy M Schmitz
Apr 26, 2017·Journal of Ethnicity in Substance Abuse·LaTrice Montgomery, Kathleen M Carroll
Apr 26, 2017·Current Opinion in Psychiatry·Riccardo De GiorgiFranco De Crescenzo
Oct 24, 2017·Expert Opinion on Emerging Drugs·Eduardo R Butelman, Mary Jeanne Kreek
Feb 21, 2018·Behavioural Pharmacology·Anna de CordéMagdalena Bujalska-Zadrożny
Jan 23, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Iris M BalodisMarc N Potenza
Apr 23, 2019·Current Opinion in Psychiatry·Jonathan Buchholz, Andrew J Saxon
Jun 12, 2019·Journal of General Internal Medicine·Brian ChanDevan Kansagara

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