A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

ELife
Isaie J ReulingTeun Bousema

Abstract

Background Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-established Controlled Human Malaria Infection model (CHMI) to induce gametocyte carriage with different antimalarial drug regimens. Methods In a single centre, open-label randomised trial, healthy malaria-naive participants (aged 18-35 years) were infected with Plasmodium falciparum by bites of infected Anopheles mosquitoes (ClinicalTrials.gov, NCT02836002). Participants were randomly allocated to four different treatment arms (n = 4 per arm) comprising low-dose (LD) piperaquine (PIP) or sulfadoxine-pyrimethamine (SP), followed by a curative regimen upon recrudescence. Male and female gametocyte densities were determined by molecular assays. Findings Mature gametocytes were observed in all participants (16/16, 100%). Gametocytes appeared 8.5-12 days after the first detection of asexual parasites. Peak gametocyte densities and gametocyte burden was highest in the LD-PIP/SP arm, and associated with the preceding asexual para...Continue Reading

References

Apr 1, 1989·Parasitology·T PonnuduraiJ H Meuwissen
Nov 5, 1997·The American Journal of Tropical Medicine and Hygiene·Q ChengA Saul
Nov 18, 1997·International Journal for Parasitology·G A Butcher
Nov 15, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M EichnerK Dietz
Dec 12, 2001·Molecular and Biochemical Parasitology·C C HermsenR W Sauerwein
Jul 27, 2002·American Journal of Epidemiology·Fabián MéndezChristopher V Plowe
Feb 1, 1951·Transactions of the Royal Society of Tropical Medicine and Hygiene·P G SHUTE, M MARYON
May 1, 2004·Tropical Medicine & International Health : TM & IH·Sarah G StaedkePhilip J Rosenthal
Oct 17, 2009·Nature Reviews. Drug Discovery·Timothy N C WellsWinston E Gutteridge
Nov 3, 2010·Lancet·Bruno MoonenGeoffrey Targett
Dec 24, 2010·Nature Reviews. Immunology·Robert W SauerweinVasee S Moorthy
Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sophie H AdjalleyDavid A Fidock
Jun 5, 2012·Vaccine·Matthew B LaurensUNKNOWN Consensus Group on Design of Clinical Trials of Controlled Human Malaria Infection
Nov 28, 2012·The Lancet Infectious Diseases·Nicholas J White
Jan 1, 2013·Trends in Parasitology·Teun BousemaRhoel R Dinglasan
May 1, 2013·Antimicrobial Agents and Chemotherapy·Michael J DelvesRobert E Sinden
Sep 17, 2013·Journal of Biomedical Semantics·Pantelis TopalisChristos Louis
Dec 10, 2014·Malaria Journal·Nicholas J WhiteFrancois H Nosten
Jun 19, 2015·PLoS Pathogens·Sandra K NilssonMatthias Marti
Jan 9, 2016·Parasitology·Will J R StoneSanna R Rijpma
Feb 26, 2016·The Journal of Infectious Diseases·Bronner P GonçalvesTeun Bousema
Nov 1, 2016·BMJ : British Medical Journal·Erika LarsonRabindra Abeyasinghe
Jul 7, 2017·PLoS Pathogens·Robert E Sinden

❮ Previous
Next ❯

Citations

Feb 28, 2018·ELife·Amanda Ross, Nicolas Mb Brancucci
Aug 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jane AchanUmberto D'Alessandro
Dec 17, 2019·Immunological Reviews·Roos M de JongTeun Bousema
Jun 5, 2020·Oral Diseases·Yi ShuaiLei Jin
Apr 22, 2020·The American Journal of Tropical Medicine and Hygiene·Mohamed Farouk ChughlayStephan Chalon
Nov 1, 2020·Trends in Parasitology·Prince B Nyarko, Antoine Claessens
Sep 23, 2021·Scientific Reports·Aurelie MiglarMuhammad Asghar

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA
transgenic

Clinical Trials Mentioned

NCT02836002

Software Mentioned

Excel
bowtie2
R
GraphPad Prism
R package rstanarm
SAS

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

© 2022 Meta ULC. All rights reserved