A randomized, multicenter, multivendor study of myocardial perfusion imaging with regadenoson CT perfusion vs single photon emission CT

Journal of Cardiovascular Computed Tomography
Ricardo C CuryRichard T George

Abstract

Myocardial CT perfusion (CTP) is a promising tool for the detection of myocardial ischemia. We hypothesize that regadenoson CTP is noninferior to regadenoson single photon emission CT (SPECT) for detecting or excluding myocardial ischemia. Patients (men ≥ 45 years; women ≥ 50 years) with known or suspected coronary artery disease (n = 124) were randomized to 1 of 2 diagnostic sequences: rest and regadenoson SPECT on day 1, then regadenoson CTP and rest CTP (and coronary CT angiography [CTA]) (CTA; same acquisition) on day 2 or regadenoson CTP and rest CTP (and CTA) on Day 1, then rest and regadenoson SPECT on day 2. Scanning platforms included 64-, 128-, 256-, and 320-slice systems. The primary analysis examined the agreement rate between CTP and SPECT for detecting or excluding reversible ischemia in ≥ 2 myocardial segments as assessed by independent, blinded readers. Complete and interpretable CTP and SPECT scans were obtained for 110 patients. Regadenoson CTP was noninferior to SPECT for detecting or excluding reversible ischemia with an agreement rate of 0.87 (95% confidence interval [CI], 0.77-0.97) and sensitivity and specificity of 0.90 (95% CI, 0.71-1.00) and 0.84 (95% CI, 0.77-0.91), respectively. The agreement rate fo...Continue Reading

References

Jan 6, 1999·Heart·J A San RománF Fernández-Avilés
Aug 2, 2005·Journal of the American College of Cardiology·Gilbert L RaffJames A Goldstein
Dec 19, 2006·Journal of the American College of Cardiology·Joanne D SchuijfJeroen J Bax
Sep 11, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ami E IskandrianUNKNOWN ADVANCE MPI Investigators
Sep 12, 2007·Circulation·Andrew J EinsteinMilena J Henzlova
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marcelo F Di CarliRory Hachamovitch
Nov 29, 2008·The New England Journal of Medicine·Julie M MillerJoão A C Lima
Mar 11, 2009·Journal of Cardiovascular Computed Tomography·Gilbert L RaffUNKNOWN Society of Cardiovascular Computed Tomography
Sep 12, 2009·Journal of the American College of Cardiology·Ron BlanksteinRicardo C Cury
Mar 10, 2010·Nature Reviews. Cardiology·Ron Blankstein, Marcelo F Di Carli
Jun 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas A HollyUNKNOWN American Society of Nuclear Cardiology
Oct 12, 2010·Clinical Radiology·C A RoobottomG Morgan-Hughes

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Citations

Feb 13, 2016·The British Journal of Radiology·Erica MaffeiFilippo Cademartiri
Jan 18, 2016·Revista Española De Cardiología·Sara SeitunCarlo Ferro
Nov 14, 2015·JACC. Cardiovascular Imaging·Pedro de Araújo GonçalvesHector M Garcia-Garcia
May 1, 2016·European Journal of Radiology·Victor Mor-AviAmit R Patel
Mar 26, 2016·European Heart Journal Cardiovascular Imaging·Ibrahim DanadJames K Min
Apr 20, 2016·Clinical Radiology·M C Williams, D E Newby
Jun 9, 2015·Journal of Cardiovascular Computed Tomography·Ricardo C Cury
Mar 16, 2017·Journal of Computer Assisted Tomography·Patricia CarrascosaGaston A Rodriguez-Granillo
Nov 10, 2017·Current Opinion in Organ Transplantation·Eduardo Castillo-LeonPaolo Fiorina
Oct 19, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sang-Geon ChoHenry Hee-Seung Bom
Jul 3, 2018·Current Cardiovascular Imaging Reports·Bryan C RamseyDustin M Thomas
May 14, 2016·Journal of Medical Imaging·Michael BindschadlerAdam M Alessio
Mar 11, 2017·The International Journal of Cardiovascular Imaging·Dong Hyun Yang, Young-Hak Kim
Dec 1, 2016·Diagnosis·Florian AndréMatthias G Friedrich
Dec 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Eun Ju Kang
Jul 22, 2017·Expert Review of Cardiovascular Therapy·T A TreibelL C Davies
Jun 18, 2020·European Radiology Experimental·M van AssenR Vliegenthart
Nov 9, 2018·BioMed Research International·Sara SeitunGian Paolo Bezante

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