A randomized, multicenter, open-label clinical trial to assess the immunogenicity of a meningococcal C vaccine booster dose administered to children aged 14 to 18 months

The Pediatric Infectious Disease Journal
Javier Diez-DomingoMenC Study Group

Abstract

A booster meningococcal C (MenC) vaccine dose is recommended after the first year of life. The objective of this study was to assess its immunogenicity and factors that modify the immunoresponse. An open label study in which 389 children 14 to 18 months of age, previously primed with 3 doses of a MenC vaccine conjugated with CRM197 (MenC-CRM) or with 2 doses of a MenC vaccine conjugated with tetanus toxoid (MenC-TT), were randomized to be boosted with either of these vaccines and a DTaP-IPV-Hib vaccine at the same time. Immunogenicity against MenC and Haemophilus influenzae type b was assessed before and 1 month after the booster dose. Before the second year booster, 44.9% of the studied children had MenC bactericidal (SBA) seroprotection rate of > or =1:8, with no differences related to the vaccine used for priming, whereas the anti Hib antibody concentration was higher in children primed with the MenC-TT (0.59; 95% CI: 0.49-0.71 vs. 0.39; 95% CI: 0.32-0.48).One month after the MenC vaccine booster 99.5% of the children had SBA > or =1:128. Children primed with MenC-TT reached higher SBA titers: 6520 (95% CI: 5359-7932) than those primed with MenC-CRM: 1903 (95% CI: 1600-2262). Children primed with MenC-CRM had SBA titers of 2...Continue Reading

Associated Clinical Trials

References

Oct 3, 2002·Journal of Medical Microbiology·P BalmerE Miller
Nov 25, 2004·JAMA : the Journal of the American Medical Association·Philippe De WalsGaston De Serres
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Citations

Apr 9, 2010·The Pediatric Infectious Disease Journal·Javier Diez-DomingoM Victoria Gutierrez-Gimeno
Feb 18, 2012·Clinical and Vaccine Immunology : CVI·Lucia H Lee, Milan S Blake
Mar 12, 2011·Emerging Infectious Diseases·Enrique Chacon-CruzJohn A Leake
Jan 15, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D Moreno-PérezUNKNOWN Comité Asesor de Vacunas de la Asociación Española de Pediatría
Oct 13, 2011·Advances in Preventive Medicine·Jacqueline M MillerYaela Baine
Jul 26, 2012·Expert Review of Vaccines·Vassiliki Papaevangelou, Nikos Spyridis
Nov 13, 2015·Expert Review of Vaccines·Al-Mamoon BadahdahAmeneh Khatami
Apr 29, 2015·Human Vaccines & Immunotherapeutics·Helen Findlow, Ray Borrow
Aug 13, 2013·Vaccine·Ray BorrowJulio A Vazquez
Dec 9, 2015·The American Journal of Tropical Medicine and Hygiene·Jennifer C Moïsi The Laboratory Evaluation Of Assays For Pneumococcus Leap Study Investigators
Oct 19, 2016·The Pediatric Infectious Disease Journal·Julie A BettingerJoenel Alcantara

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