A randomized noninferiority crossover trial of corrected count increments and bleeding in thrombocytopenic hematology patients receiving 2- to 5- versus 6- or 7-day-stored platelets

Transfusion
Sheila MacLennanLorna M Williamson

Abstract

Bacterial screening offers the possibility of extending platelet (PLT) storage to Day 7. We conducted a noninferiority, crossover trial comparing PLTs stored for 6 or 7 days versus 2 to 5 days. Stable hematology patients were allocated to receive blocks of 2- to 5- and 6- or 7-day PLTs in random order. The primary outcome was the proportion of successful transfusions during the first block, defined as a corrected count increment (CCI) of more than 4.5 at 8 to 24 hours posttransfusion. Of 122 patients with an evaluable first block, 87 (71%) and 84 (69%) had successful transfusions after 2- to 5- and 6- or 7-day PLTs of mean (SD) ages of 3.8 (1.0) and 6.4 (0.5) days, respectively. Six- or 7-day PLTs were declared noninferior to 2- to 5-day PLTs since the upper confidence interval (CI) limit was less than the predefined noninferiority margin of 10% (95% CI, -14.0% to 9.1%; p = 0.766). Logistic regression analysis gave an adjusted odds ratio of 0.86 (95% CI, 0.47-1.58; p = 0.625). Mean (SD) 8- to 24-hour CCIs were 9.4 (7.9) and 7.7 (7.1) after transfusion with 2- to 5- or 6- or 7-day PLTs (95% CI, -3.31 to 0.03; p = 0.054). The proportions of days with bleeding scores of WHO Grade 2 or higher were 13% (38/297 days) and 11% (32/296 ...Continue Reading

References

Jan 1, 1981·Cancer·A B MillerA Winkler
Jan 7, 1998·The New England Journal of Medicine·UNKNOWN Trial to Reduce Alloimmunization to Platelets Study Group
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A SchifferUNKNOWN American Society of Clinical Oncology
Jun 26, 2003·British Journal of Haematology·UNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
Jul 26, 2003·Transfusion Medicine·R Cardigan, L M Williamson
Dec 23, 2003·Transfusion Medicine Reviews·Morris A BlajchmanFederico Baeza
Jul 13, 2004·Transfusion Medicine Reviews·Joan Cid, Miquel Lozano
Aug 17, 2005·Transfusion Medicine·C P McDonaldJ A J Barbara
Sep 28, 2006·Transfusion·Sherrill J SlichterEdward L Snyder
May 29, 2010·British Journal of Haematology·Jean-Louis H KerkhoffsUNKNOWN Dutch - Belgian HOVON cooperative group
Feb 7, 2013·Vox Sanguinis·S J SlichterE Pellham
May 10, 2013·The New England Journal of Medicine·Simon J StanworthUNKNOWN TOPPS Investigators

❮ Previous
Next ❯

Citations

Sep 9, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Alesia KaplanMaria Luisa Antelo
May 3, 2016·Platelets·Peter A Smethurst
Sep 11, 2019·Transfusion·Fabienne M A van HoutJohanna G van der Bom
Mar 16, 2017·Transfusion·Andrew FlintZoe McQuilten
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Lise J EstcourtMichael F Murphy
Aug 6, 2018·Critical Care : the Official Journal of the Critical Care Forum·Cécile AubronZoe McQuilten
Mar 15, 2018·Frontiers in Medicine·Caroline SutFabrice Cognasse
Nov 2, 2017·Transfusion·Camila Caram-DeelderRutger A Middelburg
Jul 7, 2020·The Lancet. Haematology·Simon J StanworthJecko Thachil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.