A randomized, open-label, multicenter trial of topical tacrolimus for the treatment of pruritis in patients with atopic dermatitis.

Annals of Dermatology
Satoshi TakeuchiMasutaka Furue

Abstract

Pruritis caused by atopic dermatitis (AD) is not always well controlled by topical corticosteroid therapy, but use of tacrolimus often helps to soothe such intractable pruritis in clinical settings. To determine the anti-pruritic efficacy of topical tacrolimus in treating AD in induction and maintenance therapy. Prior to the study, patients were randomly allocated into two groups, induction therapy followed by tacrolimus monotherapy maintenance, and induction therapy followed by emollient-only maintenance. In the induction therapy, the patients were allowed to use topical tacrolimus and emollients in addition to a low dose (<10 g/week) of topical steroids. Patients showing relief from pruritis were allowed to proceed to maintenance therapy. Recurrence of pruritis in maintenance therapy was examined as a major endpoint. Two-thirds of patients (44/68; 64.7%) showed relief from pruritis after induction therapy. Pruritis recurred in 23.8% (5/21) of the tacrolimus monotherapy group and in 100% (21/21) of the emollient group during maintenance period, a difference that was statistically significant. Use of topical tacrolimus is effective in controlling pruritis of AD compared to emollient.

References

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Citations

Sep 4, 2015·The Journal of Dermatology·Masutaka Furue, Takafumi Kadono
Dec 6, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Takeshi NakaharaMasutaka Furue
Jan 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Kang KimHyangsook Lee
Jul 2, 2015·The Cochrane Database of Systematic Reviews·Jade Cury MartinsEdina Mk da Silva
Feb 7, 2017·The Cochrane Database of Systematic Reviews·Esther J van ZuurenBernd WM Arents
Jun 22, 2018·The Journal of Dermatology·Mamitaro OhtsukiHidemi Nakagawa
Apr 23, 2017·The British Journal of Dermatology·E J van ZuurenB W M Arents
Aug 23, 2016·The British Journal of Dermatology·H NankervisH C Williams

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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