A randomized, open-label, single-visit, crossover study simulating triple-drug delivery with Ellipta compared with dual inhaler combinations in patients with COPD

International Journal of Chronic Obstructive Pulmonary Disease
Job van der PalenRaj K Sharma

Abstract

Administering maintenance COPD therapy with a combination of multiple inhalers may increase inhaler errors. This study evaluated the potential benefits of using a single Ellipta dry powder inhaler (DPI) compared with two combinations of DPIs commonly used to deliver triple maintenance therapy. Patients receiving inhaled COPD medication were enrolled in this multicenter, randomized, open-label, placebo-device, crossover study with a 2×2 complete block design (NCT0298218), which comprised two substudies: Ellipta vs Diskus + HandiHaler (substudy 1) or Turbuhaler + HandiHaler (substudy 2). Patients demonstrated inhaler use after reading the relevant patient information leaflet (PIL). A trained investigator assessed user errors (critical errors [errors likely to result in no or significantly reduced medication being inhaled] and overall errors). The primary endpoint was the proportion of patients making ≥1 critical error after reading the PIL. The secondary endpoints included error rates during ≤2 reassessments following investigator instruction (if required), instruction time, and patient preference. After reading the PIL, significantly fewer patients made critical errors with Ellipta compared with Diskus + HandiHaler (9% [7/80] vs...Continue Reading

Citations

Jul 2, 2020·International Journal of Chronic Obstructive Pulmonary Disease·David J CollierRaj Sharma
Dec 7, 2019·Therapeutic Advances in Respiratory Disease·Federico LavoriniAnders Løkke
Oct 31, 2020·Pediatric Pulmonology·Philip HalversonRaj Sharma
May 11, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C Victor SpainHubert Chen
Jun 11, 2021·ERJ Open Research·David M G HalpinChris Compton

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Clinical Trials Mentioned

NCT02982187

Software Mentioned

Diskus
HandiHaler
Turbuhaler
Ellipta

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