A randomized, open labeled study comparing the serum levels of cobalamin after three doses of 500 mcg vs. a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy

The Korean Journal of Pain
Amrita SilSameer Rao

Abstract

Vitamin B12 deficiency has been associated with peripheral neuropathy, loss of sensation in the peripheral nerves, and weakness in the lower extremities. Methylcobalamin is the most effective analogue of vitamin B12 used to treat or prevent the complications associated with vitamin B12 deficiency. The current study aimed to compare the serum cobalamin levels after administration of two different regimes of methylcobalamin in peripheral neuropathy patients. The present study was a prospective, randomized, comparative study. The study consisted of two parallel groups, group A (methylcobalamin 500 µg injection intramuscularly three times a week) and group B (methylcobalamin 1500 µg injection intramuscularly once a week). A control group of healthy volunteers was also included. A total of 24 patients (12 in each group) were included in the study. Five healthy volunteers were also included as a control in each group. At the end of treatment, serum cobalamin levels were significantly (P = 0.028) higher in group A (1892.08 ± 234.50) as compared with group B (1438.5 ± 460.32). The serum cobalamin levels in Group A healthy volunteers were also two times higher than that of group B (P = 0.056). Both the LANSS scale and DN4 questionnaire ...Continue Reading

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Citations

May 7, 2020·Pain Practice : the Official Journal of World Institute of Pain·Gang XuKai Hua Ding
Jul 30, 2020·Nutrients·Thomas JulianPanagiotis Zis
Sep 4, 2019·Current Treatment Options in Neurology·Vanessa BauteFatemeh Sadeghifar
Jul 1, 2021·Current Molecular Pharmacology·Mayur Bhimrao KaleAman Upaganlawar

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