A randomized phase II study of pemetrexed or RAD001 as second-line treatment of advanced non-small-cell lung cancer in elderly patients: treatment rationale and protocol dynamics

Clinical Lung Cancer
Cesare GridelliFortunato Ciardiello

Abstract

In the current clinical trial summary, we present a randomized phase II trial of pemetrexed or RAD001 as second-line treatment of elderly patients with advanced non-small-cell lung cancer. The molecular and clinical rationale is reviewed. The primary endpoint is progression-free survival, and secondary endpoints include objective tumor response rates, disease control rates, safety, tolerability, and overall survival. Based on the statistical design, the investigators plan to enroll 92 elderly patients, 46 per arm.

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Citations

Jun 24, 2010·Expert Opinion on Investigational Drugs·Sébastien AlbertEric Raymond
Mar 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nobuyuki YamamotoMinori Koshiji
Jan 22, 2009·Cancer Treatment Reviews·Eric J AveryApar Kishor Ganti
Feb 29, 2008·The Oncologist·Cesare GridelliAntonio Rossi

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