A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis

Journal of Clinical and Diagnostic Research : JCDR
Mohammad Mahdi KooshyarAmir Abbas Azarian

Abstract

Oral Mucositis (OM) is a serious complication of chemotherapy that results in painful debilitating inflammation that sometimes ends in interruption of treatment. The study evaluated the effect of quercetin (a natural flavonoid) on preventing and treating chemotherapy induced OM in patients with blood malignancies. Materials and Methods: This double-blind, placebo controlled randomized trial was carried out on 20 adult patients who underwent high dose chemotherapy for blood malignancies. Patients were divided into two groups (10 patients in the intervention group and 10 patients in the control group). Patients in the intervention group were administered 250 mg quercetin capsules twice daily for four weeks. Nine out of 20 patients developed OM (three in the intervention group and six in the control group). The incidence of OM was lower in the intervention group although it was not statistically significant (p=0.189). The mean severity of OM was higher in the intervention group (2.6 vs 2). Healing time, age, gender, type of malignancy, drug type and duration of OM were not different in two groups. The incidence of mucositis was lower in the quercetin group, but mucositis was more severe in the intervention group, which may be due ...Continue Reading

Citations

Oct 12, 2018·PLoS Neglected Tropical Diseases·Ana Teresa Azevedo SachettoMarcelo Larami Santoro
Nov 22, 2018·Frontiers in Pharmacology·Qing-Yu ZhangLing-Dong Kong
Mar 7, 2021·Pharmaceuticals·Paula Garcia-OliveiraMiguel Angel Prieto
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A AlmatroodiArshad Husain Rahmani
Jan 21, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alexander T SougiannisE Angela Murphy
Jul 3, 2021·Journal of Oncology·Mandana LotfiAli Akbar Moghadamnia

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