A Randomized, Placebo-Controlled, Double-Blind, Prospective Clinical Trial of Botulinum Toxin Type A in Prevention of Hypertrophic Scar Development in Median Sternotomy Wound

Aesthetic Plastic Surgery
Yue-Hua LiDa-Hai Hu

Abstract

Linear hypertrophic scar is a common surgical problem that can be difficult to manage, especially for the median sternotomy scar. Botulinum toxin type A (BTA) is widely used in cosmetic surgery and has been shown to improve scar quality recently. The aim of this study was to evaluate the efficacy of BTA injected in the early postoperative of median sternotomy on preventing scar formation. In this prospective randomized controlled trial, 19 consecutive patients who underwent median sternotomy were enrolled. The median sternotomy wound in each patient was divided into the upper half and the lower half. Both halves of the wound were randomized to receive the treatment with either BTA or normal saline. At 6-month follow-up, scars were assessed using the Vancouver Scar Scale, scar widths were measured, and patients were asked to evaluate their overall satisfaction. Seventeen patients with median sternotomy wounds completed the entire study. At 6-month follow-up, the mean Vancouver Scar Scale score for the BTA-treated group was 3.44 ± 1.68 and for the normal saline control group was 6.29 ± 2.39, and there was a statistically significant difference between the two groups (P < 0.05). There were also significant improvements in scar wid...Continue Reading

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Citations

Mar 1, 2019·The Journal of Craniofacial Surgery·Jason J YooSeth R Thaller
Jan 25, 2020·The Journal of Craniofacial Surgery·Sen ChenYangqun Li
Jul 9, 2020·Scars, Burns & Healing·Catrin Sohrabi, Ioannis Goutos
Jul 12, 2020·American Journal of Clinical Dermatology·Tina S Alster, Iris S Harrison
Jul 7, 2020·BioMed Research International·Na ZhouYuhong Wang
Apr 20, 2021·Anais Brasileiros De Dermatologia·Renato Luiz BaldisseraDeborah Skusa de Torre
Jun 15, 2021·Seminars in Plastic Surgery·Shayan M SarramiRobert F Dempsey
Nov 25, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Wareeporn DisphanuratPeera Thienpaitoon
Jul 3, 2021·Scientific Reports·Zhiyou ChenGuangshuai Li

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