A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder

The American Journal on Addictions
Louisa G SylviaMichael J Ostacher

Abstract

Topiramate is effective for alcohol use disorders (AUDs) among non-psychiatric patients. We examined topiramate for treating comorbid AUDs in bipolar disorder (BD). Twelve participants were randomized to topiramate or placebo for 12 weeks. The topiramate group, with two out of five participants (40%) completing treatment, experienced less improvement in drinking patterns than the placebo group, with five out of seven participants (71%) completing treatment. Topiramate did not improve drinking behavior and was not well-tolerated. This study failed to recruit adequately. Problems surrounding high attrition, a small study sample, and missing data preclude interpretation of study findings. This is the first randomized, placebo-controlled trial of topiramate for AUDs in BD.

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Citations

Mar 17, 2017·The American Journal of Drug and Alcohol Abuse·Ihsan M Salloum, Edson Sherwood Brown
May 12, 2019·Bipolar Disorders·Alexandria S ColesTony P George
Aug 4, 2016·Neurotoxicity Research·Patrycja KleczkowskaMagdalena Bujalska-Zadrozny
Jul 3, 2017·CNS Drugs·Andrew NaglichE Sherwood Brown
Jan 7, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E Sherwood BrownShane Tipton
Apr 10, 2021·Frontiers in Psychiatry·Heinz GrunzeUlrich W Preuss

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