A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome

Fertility and Sterility
Dorte GlintborgMarianne Andersen

Abstract

To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). Randomized placebo-controlled study. Academic tertiary care medical center. Thirty insulin-resistant PCOS patients. Sixteen weeks of pioglitazone (30 mg/day) or placebo treatment. Twenty-four-hour 20 min integrated blood sampling for measurement of cortisol and 24 h urinary excretion of steroid metabolites. Relative 5alpha-reductase activity was evaluated by allotetrahydrocortisol (alloTHF)/THF and androsterone/etiocholanolone (A/E) ratios. Delta values denoted changes during the treatment period (16 weeks--basal). Pyridostigmine growth hormone (GH) stimulation tests were performed, and testosterone (T), dihydrotestosterone (DHT), DHEA, DHEAS, adiponectin, and insulin-like growth factor I (IGF-I) were measured before and after intervention. Insulin sensitivity, GH, adiponectin, and IGF-I significantly increased during pioglitazone treatment, whereas alloTHF/THF levels significantly decreased. Delta alloTHF/THF levels inversely correlated with Delta adiponectin levels. Delta A/E ratio inversely correlated with Delta IGF-I and Delta peak GH during GH stimulation tests. No sig...Continue Reading

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Citations

Jul 11, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Mark O GoodarziRicardo Azziz
Nov 7, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katrine Hass RubinBo Abrahamsen
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Feb 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dorte Glintborg, Marianne Andersen
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Sep 3, 2019·Nutrition and Cancer·Sama AghababayanGity Sotoudeh
Feb 29, 2020·The Journal of Clinical Endocrinology and Metabolism·David Q StoyeRebecca M Reynolds
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