A randomized placebo-controlled trial of the efficacy and safety of a terbinafine, florfenicol and betamethasone topical ear formulation in dogs for the treatment of bacterial and/or fungal otitis externa

BMC Veterinary Research
S L ForsterS B King

Abstract

Treatment of infected otitis externa (OE) relies on the topical application of specific formulations that most often contain an antibiotic, an antifungal and a glucocorticoid. This study is to report the results of a randomized, placebo-controlled field trial evaluating the efficacy and safety of OSURNIA™ (Elanco Animal Health, a division of Eli Lilly and Company, Greenfield, IN), a novel topical ear medication containing florfenicol, terbinafine and betamethasone acetate in an adaptable gel. The study includes 284 dogs with bacterial and/or fungal OE who were randomly assigned to receive two doses of Osurnia or its vehicle, one week apart. Dogs were evaluated at various time points through Day 45, and a total clinical score (TCS) was calculated based on pain, erythema, exudate, swelling, odor and ulceration. The primary outcome measure was the rate of treatment success (RTS), defined as a TCS of 0, 1 or 2 on Day 45. Before and after treatment, a "clap test" was performed to subjectively assess hearing, and blood and urine were collected for routine clinical pathology. The RTS was significantly higher in ears treated with Osurnia (64.78%) than with placebo (43.42%). There was no significant interaction between efficacy and dura...Continue Reading

References

Apr 6, 1999·Archives of Otolaryngology--head & Neck Surgery·M OhyamaY Miyazaki
Sep 13, 2000·Journal of Food Protection·A Hinton, K D Ingram
Nov 25, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·K C TaterH N Erb
Mar 10, 2004·Journal of the American Animal Hospital Association·Christine A Graham-Mize, Edmund J Rosser
Jan 15, 2014·PloS One·Aline Rodrigues HoffmannJan S Suchodolski
Aug 19, 2014·Veterinary Dermatology·Tim Nuttall, Emmanuel Bensignor

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Citations

Mar 18, 2020·Frontiers in Cellular and Infection Microbiology·Jacques Guillot, Ross Bond
Mar 21, 2020·BMC Veterinary Research·Adolfo Maria TambellaAlessandro Fruganti
Jul 1, 2021·Veterinary Dermatology·Johann M BooneAnke Hendricks

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