A randomized placebo-controlled trial of preoperative tranexamic acid among women undergoing elective cesarean delivery

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Ahmed M MagedMaha H Elsissy

Abstract

To study the efficacy and safety of preoperative intravenous tranexamic acid to reduce blood loss during and after elective lower-segment cesarean delivery. A single-blind, randomized placebo-controlled study was undertaken of women undergoing elective lower-segment cesarean delivery of a full-term singleton pregnancy at a center in Cairo, Egypt, between November 2013 and November 2014. Patients were randomly assigned (1:1) using computer-generated random numbers to receive either 1g tranexamic acid or 5% glucose 15minutes before surgery. Preoperative and postoperative complete blood count, hematocrit values, and maternal weight were used to calculate the estimated blood loss (EBL) during cesarean, which was the primary outcome. Analyses included women who received their assigned treatment, whose surgery was 90minutes or less, and who completed follow-up. Analyses included 100 women in each group. Mean EBL was significantly higher in the placebo group (700.3±143.9mL) than in the tranexamic acid group (459.4±75.4mL; P<0.001). Only six women, all in the placebo group, experienced an EBL of more than 1000mL. There were no reports of thromboembolic events up to 4weeks postoperatively. Preoperative administration of tranexamic acid ...Continue Reading

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Citations

Apr 3, 2016·Best Practice & Research. Clinical Anaesthesiology·Oliver M Theusinger, Donat R Spahn
Apr 26, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Jul 16, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ahmed M MagedWesam S Deeb
Jul 22, 2017·Journal of Intensive Care·Takeshi NishidaKazuma Yamakawa
Feb 2, 2020·BMC Pregnancy and Childbirth·Loïc SentilhesUNKNOWN TRAAP2 Study Group and the Groupe de Recherche en Obstétrique et Gynécologie (GROG)
Feb 7, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Lisa AllenUNKNOWN FIGO Placenta Accreta Diagnosis and Management Expert Consensus Panel
Oct 17, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Moutaz M El-SherbiniMariam A Dawoud
Apr 30, 2021·The New England Journal of Medicine·Loïc SentilhesUNKNOWN Groupe de Recherche en Obstétrique et Gynécologie
Aug 4, 2021·International Journal of Obstetric Anesthesia·A ShanderL Sentilhes
Sep 14, 2021·Acta Anaesthesiologica Scandinavica·Tomi HurskainenSylvain Boet
Sep 29, 2021·American Journal of Obstetrics and Gynecology·Ioannis Bellos, Vasilios Pergialiotis

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