A randomized, prospective trial of deep venous thrombosis prophylaxis in aortic surgery

Archives of Surgery
L A KillewichW R Flinn

Abstract

To study the incidence of postoperative deep venous thrombosis (DVT) in patients undergoing elective aortic reconstruction and to determine if aggressive DVT prophylaxis would reduce the incidence of DVT in these patients. Randomized, prospective trial. University hospital and Veterans Affairs hospital. One hundred patients undergoing aortic reconstruction for aneurysmal or occlusive disease randomized to receive DVT prophylaxis (treatment group) or no prophylaxis (control group). Exclusion criteria included a history of DVT, long-term anticoagulant use, or a malignant neoplasm. During the study period, 12 patients were ineligible for follow-up. Ninety-eight patients completed the trial, including 50 patients in the treatment group and 48 patients in the control group. Two patients in the control group died postoperatively of unrelated causes. Patients in the treatment group received DVT prophylaxis using a combination of low-dose heparin sodium therapy (5000 U every 12 hours) and calf-length intermittent mechanical compression devices. Control patients received no DVT prophylaxis. The occurrence of acute lower extremity DVT diagnosed by interval venous duplex ultrasound scan surveillance performed on postoperative days 1, 3, a...Continue Reading

Citations

Oct 12, 2010·Journal of Thrombosis and Thrombolysis·Gregg StashenkoVictor F Tapson
Mar 10, 2009·Journal of Vascular Surgery·Emmanuel de MaistreEric F Steinmetz
Mar 27, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Andrew NicolaidesUNKNOWN International Union of Angiology and Union Internationale du Phlebologie
Jan 24, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D Bergqvist
Sep 9, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M Bani-HaniH Al-Khaffaf
Feb 7, 2018·Frontiers in Medicine·Milena D StojanovicRadmilo J Janković
May 16, 2007·ANZ Journal of Surgery·Donald G MacLellan, John P Fletcher
Nov 6, 2018·The Cochrane Database of Systematic Reviews·Ashwin SachdevaTimothy Lees
Feb 7, 2008·The Cochrane Database of Systematic Reviews·M G Bani-HaniI Jaradat
Aug 25, 2000·Journal of Vascular Surgery·M A CahanL A Killewich
Sep 12, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Tarek HaykalThomas L Ortel

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