A randomized study comparing glucagon and hyoscine N-butyl bromide before endoscopic retrograde cholangiopancreatography

Scandinavian Journal of Gastroenterology
F Y ChangS D Lee

Abstract

This study tried to resolve whether glucagon is a better premedication for endoscopic retrograde cholangiopancreatography (ERCP). We first measured the basal blood sugar and amylase levels. Then an endoscope was placed in the duodenum without premedication, and basal pulse and duodenal peristaltic rates were measured. ERCP began after studied subjects were randomly premedicated with either 1 mg glucagon (n = 38) or 40 mg hyoscine N-butyl bromide (n = 36) intravenously. Ten minutes later the variables were measured again. Glucagon elicited hyperglycemia whereas hyoscine N-butyl bromide manifested an anticholinergic effect. No difference was found between these two groups with regard to the necessary interval for ERCP (20.6 +/- 14.1 min versus 21.4 +/- 14.7 min; NS) or the success rate for cholangiopancreatography (92.1% versus 91.7%; NS). Neither hyperamylasemia nor pancreatitis was preventable when glucagon was used. The two premedications appear equally effective in the performance of ERCP.

References

Apr 1, 1977·Gut·P B Cotton
Jan 30, 1979·Gastrointestinal Radiology·R E MillerR L Brunelle
May 1, 1978·Gastrointestinal Endoscopy·D PelotL Fridhandler
May 1, 1975·Gastrointestinal Endoscopy·S E Silvis, J A Vennes
May 1, 1992·Radiology·D D Maglinte, S M Chernish
May 1, 1991·Pancreas·S Sherman, G A Lehman
Oct 1, 1990·Radiology·S M Chernish, D D Maglinte
Nov 1, 1990·Gastrointestinal Endoscopy·D WeissmanP Dave
Nov 1, 1988·Investigative Radiology·S M ChernishR L Brunelle
Oct 1, 1987·Investigative Radiology·A J RotheB Keramati
May 1, 1974·Gastrointestinal Endoscopy·M HradskyH Ostberg
May 22, 1971·British Medical Journal·M J KnightR Smith
Jun 1, 1984·Clinical Nuclear Medicine·M K KarimeddiniD A Mucci

❮ Previous
Next ❯

Citations

Nov 29, 2012·World Journal of Gastrointestinal Endoscopy·Tomas Sjöberg BexeliusMats Lindblad
Apr 29, 2008·Gastrointestinal Endoscopy·Shyam Menon
Apr 9, 2005·World Journal of Gastroenterology : WJG·Shuo-Dong WuMin-Fei Wang
Aug 18, 2006·Anaesthesia and Intensive Care·S J Martindale
Sep 10, 2020·Clinical Pharmacology : Advances and Applications·Hassan SalmanroghaniRoham Salmanroghani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.