A randomized study to evaluate the effect of exercise on fatigue in people with relapsing-remitting multiple sclerosis treated with fingolimod

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Mathias MäurerKlaus Pfeifer

Abstract

Fatigue is a major symptom of multiple sclerosis (MS) in patients, and it has been shown to improve with physical exercise. Although fingolimod might lessen fatigue, it is unclear how patients treated with fingolimod react to physical activity regarding fatigue. This study evaluated the effect of an exercise intervention on fatigue in relapsing-remitting MS patients receiving fingolimod. People with MS (PwMS) were randomized to either a structured internet-based exercise program (e-training) or no e-training intervention. The primary endpoint was the change in the Modified Fatigue Impact Scale (mFIS) after six months. The primary analysis showed no statistically significant difference between groups in the mFIS change. Subgroup analyses revealed a beneficial effect of physical exercise for PwMS with low aerobic capacity and with low aerobic capacity plus more severe fatigue. The incidence of adverse events was similar in both groups. No cardiovascular events were reported. The majority of PwMS were relapse free. Physical exercise benefits on fatigue may depend on the physical capacity of the patient and requires individualized training. Consistent with previous studies, these results suggest that physical exercise generally doe...Continue Reading

References

Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D FiskW F Schlech
Oct 3, 2002·Multiple Sclerosis : Clinical and Laboratory Research·R A RudickS Reingold
Jan 26, 2006·Journal of the Neurological Sciences·S Pittion-VouyovitchH Vespignani
Sep 21, 2007·Multiple Sclerosis : Clinical and Laboratory Research·U DalgasT Ingemann-Hansen
Nov 21, 2007·Patient Education and Counseling·Vicki S ConnLori M Brown
Nov 19, 2008·Health and Quality of Life Outcomes·Olympia HadjimichaelUNKNOWN North American Research Committee on Multiple Sclerosis
Oct 6, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Robert W MotlDavid C Mohr
Apr 7, 2011·Multiple Sclerosis : Clinical and Laboratory Research·A K AndreasenU Dalgas
Jul 8, 2011·Multiple Sclerosis : Clinical and Laboratory Research·A TallnerM Mäurer
Jan 12, 2012·Journal of Rehabilitation Research and Development·Deirdre DlugonskiEdward McAuley
Mar 22, 2012·Therapeutic Advances in Neurological Disorders·Ulrik Dalgas, Egon Stenager
May 2, 2012·The International Journal of Behavioral Nutrition and Physical Activity·Cally A DaviesW Kerry Mummery
Nov 24, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·James H Rimmer
Dec 14, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Ayse KuspinarNancy E Mayo
Mar 5, 2013·Applied Psychology. Health and Well-being·Milena KoringRalf Schwarzer
Jun 22, 2013·Psychosomatic Medicine·Lara A PiluttiSteven J Petruzzello
Feb 20, 2014·Journal of Medical Internet Research·Carol A MaherCorneel Vandelanotte
May 21, 2014·Journal of Psychosomatic Research·Ipek EnsariLara A Pilutti
Jun 2, 2014·Journal of the Neurological Sciences·Lara A PiluttiAmy E Latimer-Cheung
Oct 21, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·U DalgasE Stenager
Feb 26, 2015·Archives of Physical Medicine and Rehabilitation·Melissa PearsonNeil Smart
Jan 12, 2016·Archives of Physical Medicine and Rehabilitation·René StreberKlaus Pfeifer
Feb 21, 2016·Archives of Physical Medicine and Rehabilitation·Matthew E PlattaLara A Pilutti
Oct 6, 2016·International Journal of Molecular Sciences·Alexander TallnerKlaus Pfeifer
Jan 31, 2017·Journal of the Neurological Sciences·Martin Langeskov-ChristensenUlrik Dalgas

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Citations

Dec 27, 2018·Neurorehabilitation and Neural Repair·Jessica F Baird, Robert W Motl

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Methods Mentioned

BETA
mFIS

Clinical Trials Mentioned

NCT01490840

Software Mentioned

WEIMuS
SAS

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