A Randomized Trial Comparing the Efficacy of Methylene Blue Dye Alone Versus Combination of Methylene Blue Dye and Radioactive Sulfur Colloid in Sentinel Lymph Node Biopsy for Early Stage Breast Cancer Patients.

Indian Journal of Surgical Oncology
Vikas GuptaB Madhunarayana

Abstract

Although sentinel lymph node biopsy (SLNB) has become a standard of care for management of axilla in breast cancer patients, the technique of SLNB is still not well defined. Unlike radioactive sulfur colloid which requires nuclear medicine facilities, methylene blue dye is readily available. The purpose of this study is to validate the use of methylene blue dye alone for SLNB in early breast cancer patients. 60 patients of early breast cancer were randomized to receive either methylene blue alone (Group A-30 patients) or a combination of both methylene blue and radioactive colloid (Group B-30 patients) for detection of sentinel lymph nodes. Sentinel lymph node biopsy was done followed by complete axillary dissection in all patients. In both Groups A and B, sentinel node was identified in all 30 patients, giving identification rate of 100%. In group A, sentinel node was the only positive node in 1 patient, with a false-positive rate of 14.2%. The negative predictive value was 91.3%. The sensitivity of the procedure in predicting further axillary disease was 75% with a specificity of 95.45%. The overall accuracy was 90%. In group B, sentinel node was the only positive node in 2 cases, giving a false-positive rate of 28.7%. The ne...Continue Reading

References

Mar 12, 1999·Japanese Journal of Clinical Oncology·S Imoto, T Hasebe
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M McMastersM J Edwards
Apr 11, 2001·Journal of the American College of Surgeons·A LucciL Wilson
Apr 24, 2001·The European Journal of Surgery = Acta Chirurgica·J FrisellR Danielsson
Jul 13, 2001·American Journal of Surgery·T SmillieN van der Westhuizen
Nov 16, 2001·Journal of the American College of Surgeons·N Klauber-DeMoreH S Cody
Oct 18, 2002·American Journal of Surgery·Walter D BlessingGeorge M Fuhrman
Apr 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H H HartgrinkM Sasako
Oct 23, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z RadovanovicD Radovanovic
Nov 4, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P VargheseR Carpenter
Jun 29, 2007·Annals of Surgical Oncology·James E GervasoniBlake Cady
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronald C ChenJennifer R Bellon
Aug 22, 2009·Nuclear Medicine Communications·Anna Domènech-VilardellJosep Martín-Comín
May 1, 2010·Japanese Journal of Clinical Oncology·Xiao SunTai-yu Li

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Citations

Aug 17, 2021·Methods and Applications in Fluorescence·Hazel L Stewart, David J S Birch
Aug 3, 2021·Minerva Surgery·Sonia BoveGiorgia Garganese

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