A randomized trial of a single dose of oral dexamethasone for mild croup

The New England Journal of Medicine
Candice L BjornsonPediatric Emergency Research Canada Network

Abstract

The benefits of dexamethasone treatment for moderate-to-severe croup are well established. However, most children with croup have mild symptoms, and it is unknown whether they would derive the same degree of benefit from dexamethasone treatment as children with more severe disease. We conducted a double-blind trial at four pediatric emergency departments in which 720 children with mild croup were randomly assigned to receive one oral dose of either dexamethasone (0.6 mg per kilogram of body weight) or placebo. The children had mild croup, as defined by a score of < or =2 on the croup scoring system of Westley et al. The primary outcome was a return to a medical care provider for croup within seven days after treatment. The secondary outcome was the presence of ongoing symptoms of croup on days 1, 2, and 3 after treatment. Other outcomes included economic costs, hours of sleep lost by the child, and stress on the part of the parent in relation to the child's illness. Baseline clinical characteristics were similar in the two groups. Return to medical care was significantly lower in the dexamethasone group (7.3 percent vs. 15.3 percent, P<0.001). In the dexamethasone group, there was quicker resolution of croup symptoms (P=0.003),...Continue Reading

Associated Clinical Trials

Oct 14, 2009·Andrew Dixon, Andrew Dixon

References

May 1, 1978·American Journal of Diseases of Children·C R WestleyJ G Brooks
Aug 4, 1994·The New England Journal of Medicine·T P KlassenP C Rowe
Apr 1, 1996·Archives of Pediatrics & Adolescent Medicine·D W JohnsonD M Jaffee
Apr 1, 1996·Archives of Pediatrics & Adolescent Medicine·H PatelD Johnson
Dec 1, 1995·Pediatric Pulmonology·G C Geelhoed, W B Macdonald
Sep 3, 1999·BMJ : British Medical Journal·M AusejoT P Klassen
Dec 26, 2001·Archives of Pediatrics & Adolescent Medicine·J W LuriaR M Ruddy
Mar 27, 2004·The New England Journal of Medicine·Tsu F YehCheng H Tsai

❮ Previous
Next ❯

Citations

Oct 24, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alex ZhavoronkovAlexey Moskalev
Jun 20, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kevin Yee, Robin G Cox
Feb 26, 2008·Lancet·Candice L Bjornson, David W Johnson
Dec 24, 2004·The New England Journal of Medicine·Louis Vernacchio, Allen A Mitchell
Jan 25, 2008·The New England Journal of Medicine·James D Cherry
Dec 27, 2005·The Pediatric Infectious Disease Journal·James D Cherry
Dec 13, 2005·Pediatric Emergency Care·Candice Leigh Bjornson, David W Johnson
Jun 5, 2010·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Terry P KlassenYehezkel Waisman
Jun 27, 2008·Pediatric Emergency Care·Meredith Louise BorlandAmanda Doreen Esson
Jul 27, 2010·Pediatric Emergency Care·Terry P KlassenUNKNOWN PERN
Jan 13, 2010·Clinical Microbiology Reviews·John S Tregoning, Jürgen Schwarze
Apr 11, 2008·Clinical Microbiology Reviews·W Garrett NicholsMichael Boeckh
Dec 18, 2013·BMJ : British Medical Journal·Matthew ThompsonUNKNOWN TARGET Programme Team
Jan 6, 2012·International Journal of Otolaryngology·Gustavo NinoMichael Schwartz
Jun 23, 2010·BMC Health Services Research·Greta G CummingsCarole A Estabrooks
Nov 10, 2013·PloS One·Lisa HartlingTerry P Klassen
Oct 16, 2015·Fundamental & Clinical Pharmacology·Aziz EghbaliManijeh Kahbazi
Jan 1, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Joel D HudginsFlorence T Bourgeois
Nov 13, 2015·The Journal of the American Dental Association·Márcia RezendeStella Kossatz
Dec 9, 2009·Advances in Pediatrics·Kam-Lun Hon, Alexander K C Leung
Feb 8, 2005·Pediatric Annals·Joseph B Domachowske, Helene F Rosenberg
Apr 26, 2008·Otolaryngologic Clinics of North America·Steven E Sobol, Syboney Zapata
May 26, 2007·Annales Françaises D'anesthèsie Et De Rèanimation·F UghettoA Charpentier
Apr 1, 2006·Pediatric Clinics of North America·Keyvan Rafei, Richard Lichenstein
Aug 6, 2015·The Journal of Emergency Medicine·Sherri L RudinskyJohn T Kanegaye
Aug 18, 2009·Emergency Medicine Australasia : EMA·Milana Dobrovoljac, Gary C Geelhoed
Feb 19, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Keiko Oda, Yukiyo Yamamoto
Feb 9, 2012·Emergency Medicine Australasia : EMA·Milana Dobrovoljac, Gary C Geelhoed
Mar 7, 2014·Pediatric Pulmonology·Argyri PetrocheilouAthanasios G Kaditis
Mar 11, 2005·Expert Opinion on Pharmacotherapy·Robert Bruce WrightTerry P Klassen
Sep 27, 2014·Indian Journal of Pediatrics·B S SharmaHari Mohan
Jun 5, 2007·Annales Françaises D'anesthèsie Et De Rèanimation·W Habre, O Paut
Jun 18, 2017·Medwave·Elizabeth Muñoz-Osores, Deidyland Arenas
Aug 23, 2018·The Cochrane Database of Systematic Reviews·Allison GatesTerry P Klassen
Sep 8, 2019·Hospital Pediatrics·Jake WeatherlyMarc Berg
May 29, 2020·Trials·Stephen B FreedmanUNKNOWN KidsCAN-Pediatric Emergency Research Canada (PERC) Innovative Pediatric Clinical Trials DOSE-AGE Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.