PMID: 9555794Apr 29, 1998Paper

A randomized trial of acidified nitrite cream in the treatment of tinea pedis

Journal of the American Academy of Dermatology
R WellerN Benjamin

Abstract

Nitric oxide is continually released from normal skin and has antimicrobial effects. An acidified nitrite cream releases supraphysiologic concentrations of nitric oxide and is fungicidal in vitro. The purpose of this study was to assess the efficacy of an acidified nitrite cream as treatment for tinea pedis. Sixty patients were recruited with both a clinical diagnosis of tinea pedis and hyphae identified on direct microscopy; they were randomly placed into an active group treated with twice-daily application of a mixture of 3% salicylic acid in aqueous cream and 3% nitrite in aqueous cream for 4 weeks and a control group treated with 3% salicylic acid in aqueous cream and aqueous cream alone. Nineteen patients completed the trial in the active group and 16 patients in the control group. Mycologic cure (negative results on microscopy and culture) and clinical improvement were measured at 0, 2, and 4 weeks and after a 2-week interval with no treatment. At the end of the treatment period, 18 of the 19 patients in the active group were mycologically cured as were 11 of 16 in the control group (p = 0.042). Two weeks after the cessation of treatment, 13 of 19 patients in the active group were mycologically cured and 5 of 16 in the co...Continue Reading

References

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Citations

Aug 11, 2005·Journal of Cutaneous Medicine and Surgery·Chris C MillerBrian Kunimoto
Sep 25, 2012·Journal of Materials Science. Materials in Medicine·Rachna N DaveVayalam P Venugopalan
Jun 16, 2005·International Journal of Antimicrobial Agents·M AnyimM Wilks
Dec 20, 2002·Clinics in Dermatology·Andreas Katsambas, Christine Stefanaki
Jan 3, 2008·Nature Reviews. Drug Discovery·Jon O LundbergMark T Gladwin
Jun 16, 2004·Nature Reviews. Microbiology·Jon O LundbergNigel Benjamin
Jun 3, 2006·Biological Chemistry·Christoph V SuschekKlaus-Dietrich Kröncke
May 11, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Allison J Kutner, Adam J Friedman
Mar 13, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Steven L PercivalEmma J Woods
Sep 6, 2003·Dermatologic Clinics·Aditya K GuptaRaza Aly
Jun 5, 2013·International Wound Journal·Shadi FarsaeiZahra Khazaeipour
May 31, 2011·Free Radical Biology & Medicine·Christopher G KevilTony Giordano
May 2, 2012·Virulence·David O SchairerAdam J Friedman
Oct 6, 2012·Nitric Oxide : Biology and Chemistry·Christian OpländerChristoph V Suschek
Oct 5, 2007·The Journal of Investigative Dermatology·Megan MowbrayRichard B Weller
May 30, 2006·Nitric Oxide : Biology and Chemistry·Richard Weller, Michael J Finnen
Jul 28, 2004·Nitric Oxide : Biology and Chemistry·M-M Cals-Grierson, A D Ormerod
Mar 8, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Samantha E RussellRussell E Morris
Dec 22, 1999·The British Journal of Dermatology·A D OrmerodN Benjamin
Jul 10, 2002·Experimental Dermatology·László VirágCsaba Szabó
Jun 1, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Abdi GhaffariAziz Ghahary
Jul 20, 2007·The Cochrane Database of Systematic Reviews·F Crawford, S Hollis
Nov 3, 2009·The Journal of Dermatological Treatment·Farideh JowkarMohammad Reza Namazi
Oct 23, 2012·Journal of Applied Microbiology·G Regev-ShoshaniC C Miller
Mar 15, 2021·Archives of Dermatological Research·Rafael A C SouzaThaís R Sudbrack
May 1, 2021·International Journal of Molecular Sciences·Tom ZimmermannAnja-Katrin Bosserhoff

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