A randomized trial of adding a plano lens to atropine for amblyopia

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Pediatric Eye Disease Investigator GroupRobert J Peters

Abstract

Some children have residual amblyopia after treatment with atropine eyedrops for amblyopia due to strabismus and/or anisometropia. We conducted a randomized clinical trial to evaluate the effectiveness of augmenting the effect of atropine by changing the lens over the fellow eye to plano in children with residual amblyopia. A total of 73 children 3 to <8 years of age (mean, 5.8 years) with stable residual amblyopia (range, 20/32 to 20/160, mean 20/63(+1)) were enrolled after at least 12 weeks of atropine treatment of the fellow eye. Participants were randomly assigned to continuing weekend atropine alone or wearing a plano lens over the fellow eye (while continuing atropine). The primary outcome was assessed at 10 weeks, and participants were followed until improvement ceased. At the 10-week primary outcome visit, amblyopic-eye visual acuity had improved an average of 1.1 lines with the plano lens and 0.6 lines with atropine only (difference adjusted for baseline visual acuity = + 0.5 line; 95% CI, -0.1 to +1.2). At the primary outcome or later visit when the best-measured visual acuity was observed, the mean amblyopic-eye improvement from baseline was 1.9 lines with the plano lens and 0.8 lines with atropine only. When amblyop...Continue Reading

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Citations

Jun 7, 2018·The British Journal of Ophthalmology·Courtney L Kraus, Susan M Culican
Aug 29, 2019·The Cochrane Database of Systematic Reviews·Tianjing LiKate Taylor
Feb 13, 2018·Proceedings. Mathematical, Physical, and Engineering Sciences·Carlo CilibertoLeonard Wossnig
Oct 1, 2020·Acta Ophthalmologica·Peter C K PangBenjamin Thompson
Feb 2, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eleni PapageorgiouIrene Gottlob
Aug 23, 2019·Indian Journal of Ophthalmology·Santhan K S GopalAbhishek Pandit

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