A randomized trial of alternative two- and three-dose hepatitis B vaccination regimens in adolescents: antibody responses, safety, and immunologic memory

Pediatrics
W M CassidyD J West

Abstract

Hoping to increase hepatitis B (HB) vaccination of adolescents, we did the following: 1) studied if modified regimens of the recombinant HB vaccine, Recombivax HB (2 or 3 doses of 5 or 10 microg given over 4 or 6 months), induce protective anti-hepatitis B surface antibody [anti-HBsAb] levels (>/=10 mIU/mL) comparable to the recommended regimen (5 microg at 0 and 1, and 6 months); 2) measured early antibody response after a single dose; and 3) assessed immunologic memory after 2- and 3-dose regimens. One thousand twenty-six adolescents were randomized to 1 of 5 treatment groups (10 microg at 0 and 4 or 0 and 6 months; 5 microg at 0 and 6 or 0, 2, and 4 or 0, 1, and 6 months) in an open trial. Anti-HBsAb was measured in all participants just before and 1 month after the last dose, and at several other times in a subset of vaccinees. Anti-HBsAb response to a booster dose 2 years later was examined to assess immunologic memory in participants vaccinated with 5 microg at 0 and 6 or 0, 1, and 6 months. All regimens induced >/=10 mIU/mL of anti-HBs in >/=95% of vaccinees. Geometric mean titers ranged from 674.8 to 3049.4 mIU/mL. Geometric mean titers were higher with regimens using the following: 1) 10 versus 5 microg; 2) 3 versus 2 ...Continue Reading

Citations

Dec 18, 2003·Clinics in Dermatology·Peggy LinStephen K Tyring
Apr 20, 2004·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Amy B Middleman
Apr 12, 2003·The American Journal of Medicine·Josiah D RichTimothy P Flanigan
Apr 7, 2005·Nature Medicine·Paul-Henri LambertClaire-Anne Siegrist
Nov 22, 2002·The New England Journal of Medicine·Laura A KoutskyUNKNOWN Proof of Principle Study Investigators
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheila M Mackell
Jun 3, 2005·The Pediatric Infectious Disease Journal·Sharon G Humiston, Susan L Rosenthal
Nov 7, 2007·The Pediatric Infectious Disease Journal·Vijayakumar VeluSadras Panchatcharam Thyagarajan
Feb 23, 2010·The Pediatric Infectious Disease Journal·Coleen K CunninghamUNKNOWN Adolescent Medicine Trials Network for HIV/AIDS Interventions
Oct 4, 2007·Sexually Transmitted Infections·K Van HerckP Van Damme
Sep 1, 2007·Current Opinion in HIV and AIDS·Heather B Jaspan, Willem A Hanekom
Feb 7, 2002·Pharmacoepidemiology and Drug Safety
Oct 27, 2007·Expert Opinion on Biological Therapy·Mazin Barry, Curtis Cooper
Feb 6, 2007·Drug and Alcohol Dependence·Jennifer V CampbellUNKNOWN DUIT Study Team
Feb 28, 2009·Journal of Viral Hepatitis·A M NyamathiD Tyler
May 23, 2015·Human Vaccines & Immunotherapeutics·Rajiv SharmaCécile Eymin
Jun 5, 2013·Human Vaccines & Immunotherapeutics·Nelson F EngFrancisco Diaz-Mitoma
Jan 30, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Arístides Aguilar BetancourtJ C Aguilar Rubido
Nov 9, 2016·Bulletin of the World Health Organization·Andre Louis WattiauxKristine Macartney
Apr 7, 2009·Cadernos de saúde pública·Ana Rita C Motta-CastroRegina M B Martins
Feb 14, 2007·European Journal of Epidemiology·C LocquetG Vidal-Trecan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.