PMID: 8584362Nov 1, 1995Paper

A randomized trial of chloramphenicol vs. trimethoprim-sulfamethoxazole for the treatment of malnourished children with community-acquired pneumonia

The Pediatric Infectious Disease Journal
E K MulhollandB M Greenwood

Abstract

Children in developing countries who present with malnutrition often have infections, particularly pneumonia, at the time of presentation. We evaluated the initial antibiotic management of 144 Gambian children who presented for the first time with malnutrition and who had clinical or radiologic evidence of pneumonia. They were enrolled in a double blind trial of trimethoprim-sulfamethoxazole vs. chloramphenicol. Most children in the study underwent detailed investigations of bacterial and viral etiology as part of another study. The study drug was administered for a week along with oral metronidazole, vitamins and standardized nutritional therapy. Treatment failure was defined as the need for change to parenteral antibiotics during treatment, failure to respond to a week of treatment with the study drug or relapse during the following 2 weeks. There were no differences between the treatment groups in the clinical indicators of severity, etiology or radiologic findings. Thirty-three children were excluded from the analysis because of tuberculosis, inappropriate enrollment or inadequate follow-up. Of the 111 children remaining, 32 (16 in each arm of the study) failed treatment. Clinical failure was not related to in vitro antimic...Continue Reading

Citations

Sep 5, 2003·The Lancet Infectious Diseases·Sunil SazawalUNKNOWN Pneumonia Case Management Trials Group
Jan 17, 2014·Archives of Disease in Childhood·Zohra S LassiZulfiqar A Bhutta
Aug 13, 2011·Bulletin of the World Health Organization·Marzia Lazzerini, David Tickell
Nov 10, 2015·Expert Opinion on Pharmacotherapy·Cristiana M Nascimento-CarvalhoAna-Luisa Vilas-Boas
Oct 24, 2000·Tropical Medicine & International Health : TM & IH·M LarssonT Falkenberg
May 24, 2018·Paediatrics and International Child Health·Phoebe C M Williams, James A Berkley
Apr 21, 2006·The Cochrane Database of Systematic Reviews·M X Rojas, C Granados
Jun 5, 2013·The Cochrane Database of Systematic Reviews·Rakesh LodhaRavindra M Pandey

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